HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: NPHN (O60500)
Nephrin (Renal glomerulus-specific cell adhesion receptor)
Gene: NPHS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16525419
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0030838 - positive regulation of actin filament polymerization
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 1241
+	Hs
		249091 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		DSCAM_HUMAN (2-1156): 8.71e-94: 334: 13.27
+	Hs
		319121 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		NFASC_HUMAN (737-1239): 2.77e-34: 145: 13.09
+	Hs
		249923 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		NPHN_HUMAN (1-353): 4.74e-24: 112: 11.88
+	Hs
		987544 GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31		PGBM_HUMAN (608-1241): 1.67e-53: 208: 14.11
+	Dm
		1070146 NCK_DROME (1-176): 7.9e-11: 65.6: 18.42		DSCA1_DROME (546-1239): 2.59e-49: 194: 13.44
+	Hs
		319119 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		NFASC_HUMAN (737-1239): 2.77e-34: 145: 13.09
+	Hs
		319123 GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31		NFASC_HUMAN (737-1239): 2.77e-34: 145: 13.09
+	Hs
		463875 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		ROBO1_HUMAN (4-328): 4.44e-26: 118: 16.11
+	Hs
		249920 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		NPHN_HUMAN (1-353): 4.74e-24: 112: 11.88
+	Hs
		249921 YES_HUMAN (6-137): 1.81e-19: 91.7: 20.15		NPHN_HUMAN (1-353): 4.74e-24: 112: 11.88
+	Hs
		463779 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		ROBO2_HUMAN (1-284): 2e-20: 100: 15.28
+	Hs
		463845 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		TUTLB_HUMAN (520-1036): 2.9e-18: 93.2: 26.47
+	Hs
		463262 YES_HUMAN (6-137): 1.81e-19: 91.7: 20.15		TUTLB_HUMAN (520-1036): 2.9e-18: 93.2: 26.47
+	Hs
		557532 SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11		TUTLB_HUMAN (520-1036): 2.9e-18: 93.2: 26.47
+	Hs
		463707 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		KIRR1_HUMAN (450-935): 6.58e-15: 82: 23.05
+	Hs
		987864 GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31		KIRR1_HUMAN (450-935): 6.58e-15: 82: 23.05
+	Hs
		913671 VAV2_HUMAN (3-254): 1.88e-09: 61.3: 11.77		TITIN_HUMAN (1030-1238): 4.54e-10: 66.7: 11.01