HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: PKD1 (P98161)
Polycystin-1 (PC1) (Autosomal dominant polycystic kidney disease 1 protein)
Gene: PKD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	20856870
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	LRR_8~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005783 - endoplasmic reticulum GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 4303
+	Hs
		440492 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		PKD1_HUMAN (35-4303): 0: 5686: 100.00
+	Hs
		557228 SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11		PKD1_HUMAN (35-4303): 0: 5686: 100.00
+	Hs
		222117 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		LRFN4_HUMAN (33-459): 2.16e-33: 142: 14.56
+	Hs
		594024 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		LRFN4_HUMAN (33-459): 2.16e-33: 142: 14.56
+	Hs
		463515 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		SCRIB_HUMAN (3-500): 4.65e-45: 183: 14.52
+	Hs
		440072 LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59		SCRIB_HUMAN (3-500): 4.65e-45: 183: 14.52
+	Hs
		902863 BLK_HUMAN (7-204): 7.94e-20: 92.9: 19.80		LRTM2_HUMAN (1-217): 1.19e-40: 158: 22.09
+	Hs
		699877 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		FLRT1_HUMAN (41-379): 9.81e-29: 128: 13.73
+	Hs
		136441 P85B_HUMAN (21-380): 2.06e-23: 104: 12.80		FLRT1_HUMAN (41-379): 9.81e-29: 128: 13.73
+	Hs
		463248 YES_HUMAN (6-137): 1.81e-19: 91.7: 20.15		FLRT1_HUMAN (41-379): 9.81e-29: 128: 13.73