Protein: PKD1
Polycystin-1 (PC1) (Autosomal dominant polycystic kidney disease 1 protein)

Gene: PKD1
Organism: Homo sapiens
Interactions: 42
UniProt ID: P98161

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001502 - cartilage condensation
GO:0001701 - in utero embryonic development
GO:0001822 - kidney development
GO:0001889 - liver development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1022579

PKD2
Polycystin-2

8

8

Small-scale

0.982

High

1022575

FAK1
Focal adhesion kinase 1

2

17

Small-scale

0.776

High

659016

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

4

Small-scale

0.713

High

1022580

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.691

High

222055

NCK2
Cytoplasmic protein NCK2

1

10

Small-scale

0.647

High

389291

FINC
Fibronectin

1

2

Small-scale

0.647

High

557228

SRC
Proto-oncogene tyrosine-protein kinase Src

1

6

Small-scale

0.647

High

1022586

MARK2
Serine/threonine-protein kinase MARK2

1

2

Small-scale

0.647

High

1022595

HDAC9
Histone deacetylase 9

2

4

Small-scale

0.646

High

362246

ABL1
Tyrosine-protein kinase ABL1

1

6

High-throughput

0.618

High

440492

FYN
Tyrosine-protein kinase Fyn

1

6

High-throughput

0.618

High

556013

CADH1
Cadherin-1

1

5

Small-scale

0.618

High

728169

AKT1
RAC-alpha serine/threonine-protein kinase

1

5

Small-scale

0.618

High

1022577

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

2

Small-scale

0.618

High

1022578

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

4

Small-scale

0.618

High

184281

NPHP1
Nephrocystin-1

1

0

Small-scale

0.578

High

1022576

KPCZ
Protein kinase C zeta type

1

5

High-throughput

0.575

High

1022581

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

20

High-throughput

0.575

High

890710

RGS7
Regulator of G-protein signaling 7

1

3

Small-scale

0.573

High

1022587

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

Small-scale

0.552

High

1022592

LT4R2
Leukotriene B4 receptor 2

1

4

High-throughput

0.541

High

764659

CTNB1
Catenin beta-1

1

2

Small-scale

0.534

High

1022574

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.518

High

245799

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

1

4

Small-scale

0.501

High

384248

CO2A1
Collagen alpha-1(II) chain

1

1

Small-scale

0.501

High

436844

K1C18
Keratin, type I cytoskeletal 18

1

1

Small-scale

0.501

High

572806

NCF1
Neutrophil cytosol factor 1

1

4

Small-scale

0.501

High

1022590

CA054
Uncharacterized protein C1orf54

1

2

High-throughput

0.489

High

241403

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

413623

P53
Cellular tumor antigen p53

1

1

Small-scale

0.479

High

563625

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.479

High

868671

LEG7
Galectin-7

1

7

High-throughput

0.479

High

1022582

RN123
E3 ubiquitin-protein ligase RNF123

1

5

High-throughput

0.479

High

1022584

JADE1
Protein Jade-1

1

2

Small-scale

0.479

High

1022589

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

1022591

GAN
Gigaxonin

1

6

High-throughput

0.479

High

1022593

EPCIP
Exosomal polycystin-1-interacting protein

1

0

Small-scale

0.458

High

1022594

ANX10
Annexin A10

1

0

Small-scale

0.458

High

384133

CO1A1
Collagen alpha-1(I) chain

1

1

Small-scale

0.457

High

1022585

MCAF1
Activating transcription factor 7-interacting protein 1

1

2

High-throughput

0.457

High

1022583

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

1022588

TRI41
E3 ubiquitin-protein ligase TRIM41

1

1

Small-scale

0.437

High


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Last updated: 11Aug2025