HitPredict

Interactor 1: PER2 (O54943)
Period circadian protein homolog 2 (mPER2) (Circadian clock protein PERIOD 2)
Gene: PER2

Interactor 2: KC1E (Q9JMK2)
Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1)
Gene: Csnk1e

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.720

Property	Details
Experiments	21680841, 15767683, 21179498, 24413057, 23555304, 23079727
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, two hybrid, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0007623 - circadian rhythm GO:0032922 - circadian regulation of gene expression and 1 others more... GO:0042752 - regulation of circadian rhythm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1257 Mm			1 416
+	Hs
		165951 PER2_HUMAN (1-1257): 1.28e-166: 531: 76.37		KC1E_HUMAN (1-416): 6.6e-136: 397: 98.80
+	Mm
		222711 PER2_MOUSE (1-1257): 9.6e-169: 537: 100.00		KC1D_MOUSE (1-406): 2.72e-124: 367: 82.51
+	Hs
		165949 PER2_HUMAN (1-1257): 1.28e-166: 531: 76.37		KC1D_HUMAN (1-406): 3.49e-124: 367: 82.27
+	Mm
		222703 PER2_MOUSE (1-1257): 9.6e-169: 537: 100.00		KC1A_MOUSE (2-327): 2.56e-121: 357: 69.02
+	Mm
		1337560 BMAL1_MOUSE (27-612): 1.1e-121: 393: 16.33		KC1E_MOUSE (1-416): 1.27e-136: 399: 100.00
+	Hs
		126110 BMAL1_HUMAN (27-612): 4.96e-117: 380: 15.46		KC1E_HUMAN (1-416): 6.6e-136: 397: 98.80
+	Dm
		1096079 TRH_DROME (86-983): 5.52e-108: 366: 14.33		AKT1_DROME (1-332): 7.7e-119: 360: 17.94
+	Hs
		182326 PER1_HUMAN (21-1219): 2.35e-89: 318: 35.59		KC1E_HUMAN (1-416): 6.6e-136: 397: 98.80
+	Mm
		193662 PER1_MOUSE (9-1230): 1.86e-88: 315: 35.73		KC1E_MOUSE (1-416): 1.27e-136: 399: 100.00
+	Hs
		822275 HIF1A_HUMAN (81-816): 5.18e-103: 347: 12.42		KC1D_HUMAN (1-406): 3.49e-124: 367: 82.27
+	Hs
		830317 PER3_HUMAN (59-1220): 3.62e-88: 313: 30.68		KC1E_HUMAN (1-416): 6.6e-136: 397: 98.80
+	Hs
		681876 HIF1A_HUMAN (81-816): 5.18e-103: 347: 12.42		AKT1_HUMAN (5-357): 3.64e-120: 359: 18.51
+	Dm
		283732 PER_DROME (189-1125): 1.66e-96: 338: 18.03		DCO_DROME (1-339): 1.58e-122: 364: 77.29
+	Dm
		429417 PER_DROME (189-1125): 1.66e-96: 338: 18.03		KC1A_DROME (2-320): 1.91e-123: 362: 65.11
+	Hs
		182324 PER1_HUMAN (21-1219): 2.35e-89: 318: 35.59		KC1D_HUMAN (1-406): 3.49e-124: 367: 82.27
+	Mm
		193661 PER1_MOUSE (9-1230): 1.86e-88: 315: 35.73		KC1D_MOUSE (1-406): 2.72e-124: 367: 82.51
+	Hs
		649042 ARNT_HUMAN (9-756): 3.42e-93: 319: 12.61		AKT1_HUMAN (5-357): 3.64e-120: 359: 18.51
+	Hs
		181505 CLOCK_HUMAN (87-923): 2.11e-78: 278: 11.99		KC1E_HUMAN (1-416): 6.6e-136: 397: 98.80
+	Hs
		182338 PER1_HUMAN (21-1219): 2.35e-89: 318: 35.59		KC1G2_HUMAN (3-356): 2.51e-120: 357: 48.89
+	Mm
		193658 PER1_MOUSE (9-1230): 1.86e-88: 315: 35.73		KC1A_MOUSE (2-327): 2.56e-121: 357: 69.02