HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ADT2 (P05141)
ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed]
Gene: SLC25A5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	32929329, 35509820, 35256949, 24244333
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0031625 - ubiquitin protein ligase binding GO:1901526 - positive regulation of mitophagy
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 298
+	Hs
		226379 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ADT3_HUMAN (1-296): 4.83e-115: 335: 92.57
+	Hs
		226378 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ADT1_HUMAN (1-297): 1.24e-113: 331: 89.23
+	Hs
		227780 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SCMC1_HUMAN (98-297): 4.27e-45: 160: 23.27
+	Hs
		229010 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		S2513_HUMAN (2-104): 5.95e-22: 97.6: 27.18
+	Hs
		226076 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		S2512_HUMAN (2-119): 2.57e-20: 92.9: 21.01
+	Hs
		1317097 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		S2513_HUMAN (2-104): 5.95e-22: 97.6: 27.18
+	Hs
		476538 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		S2513_HUMAN (2-104): 5.95e-22: 97.6: 27.18
+	At
		221617 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		ADT3_ARATH (7-109): 2.25e-10: 62.6: 24.27
+	At
		778356 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		ADT2_ARATH (3-108): 3.16e-10: 62.2: 23.59