HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: CCNE1 (P24864)
G1/S-specific cyclin-E1
Gene: CCNE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	19946270, 24793136, 12628165
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 410
+	Hs
		227146 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CCNA1_HUMAN (15-367): 4.41e-96: 297: 20.98
+	Hs
		226419 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CCNB1_HUMAN (1-365): 5.55e-95: 293: 18.82
+	Hs
		624622 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		CCNE1_HUMAN (1-410): 2.36e-135: 395: 100.00
+	Xl
		193813 Q7SY79_XENLA (1-149): 2.25e-49: 179: 19.33		CCNE3_XENLA (7-407): 5.24e-120: 356: 58.81
+	Hs
		475349 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CCNE1_HUMAN (1-410): 2.36e-135: 395: 100.00
+	Xl
		526768 Q7SY79_XENLA (1-149): 2.25e-49: 179: 19.33		CCNB2_XENLA (5-370): 2.09e-98: 300: 19.15
+	Xl
		1186349 Q7SY79_XENLA (1-149): 2.25e-49: 179: 19.33		Q7ZYT0_XENLA (7-365): 1.93e-92: 285: 19.25