HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PTBP1 (P26599)
Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I)
Gene: PTBP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	32929329, 35509820, 35987950, 35256949
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 557
+	Hs
		226164 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PTBP3_HUMAN (1-557): 1.83e-101: 318: 74.01
+	Hs
		228185 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HNRLL_HUMAN (44-556): 3.43e-96: 304: 25.91
+	Hs
		229022 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PTBP2_HUMAN (1-557): 2.33e-92: 294: 68.40
+	Hs
		226375 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP1_HUMAN (3-375): 1.46e-44: 169: 13.58
+	Hs
		228678 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP3_HUMAN (3-375): 4.05e-44: 167: 13.42
+	Hs
		227354 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP4_HUMAN (3-378): 1.16e-43: 166: 10.62
+	Hs
		227642 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PAP1L_HUMAN (3-380): 1.08e-42: 163: 11.86
+	Hs
		226317 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SNRPA_HUMAN (361-471): 6.95e-19: 89.1: 16.38
+	Hs
		475363 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PTBP1_HUMAN (1-557): 1.59e-120: 368: 100.00
+	Hs
		226422 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HNRPL_HUMAN (15-252): 9.17e-10: 63.4: 13.31
+	Hs
		1031383 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		PABP4_HUMAN (3-378): 1.16e-43: 166: 10.62
+	Hs
		312462 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		PABP1_HUMAN (3-375): 1.46e-44: 169: 13.58
+	Hs
		312453 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		SNRPA_HUMAN (361-471): 6.95e-19: 89.1: 16.38
+	Hs
		475288 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PABP1_HUMAN (3-375): 1.46e-44: 169: 13.58
+	Hs
		475708 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PABP4_HUMAN (3-378): 1.16e-43: 166: 10.62
+	At
		983451 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PABP5_ARATH (15-272): 1.16e-29: 125: 11.19
+	Hs
		446490 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SNRPA_HUMAN (361-471): 6.95e-19: 89.1: 16.38
+	At
		1091716 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PTBP3_ARATH (358-553): 4.86e-18: 88.8: 19.90
+	Hs
		475300 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		HNRPL_HUMAN (15-252): 9.17e-10: 63.4: 13.31