HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: THIM (P42765)
3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-, EC 3.1.2.1, EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) (T1)
Gene: ACAA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 397
+	Hs
		226553 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		THIL_HUMAN (3-394): 8.52e-169: 480: 39.19
+	Hs
		228566 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		THIC_HUMAN (7-394): 4.57e-169: 480: 42.56
+	Hs
		226981 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ECHB_HUMAN (4-395): 4.83e-151: 437: 33.33
+	Sc
		477326 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		ERG10_YEAST (5-394): 6.29e-165: 469: 37.47
+	At
		1091829 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		ACCT2_ARATH (5-394): 3.26e-169: 480: 38.78
+	At
		1091700 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		THIK2_ARATH (5-394): 1.35e-162: 466: 37.59
+	Hs
		475530 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ECHB_HUMAN (4-395): 4.83e-151: 437: 33.33