HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: JIP3 (Q9UPT6)
C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3)
Gene: MAPK8IP3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0048471 - perinuclear region of cytoplasm GO:0050821 - protein stabilization
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 1336
+	Hs
		225985 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		JIP4_HUMAN (6-1336): 0: 671: 54.25
+	Hs
		226680 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MYH10_HUMAN (243-769): 2.9e-24: 113: 8.89
+	Hs
		226679 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MYH9_HUMAN (228-774): 4.87e-21: 102: 8.04
+	Hs
		148181 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CTRO_HUMAN (1-425): 1.46e-17: 91.4: 9.17
+	Hs
		226436 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DESP_HUMAN (27-706): 3.94e-16: 86.8: 11.43
+	Hs
		226028 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ROCK2_HUMAN (2-348): 1.31e-13: 78.3: 7.20
+	Hs
		227904 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KI21A_HUMAN (40-567): 1.66e-13: 78: 9.65
+	Hs
		227694 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FKB15_HUMAN (1-294): 8.91e-12: 72.2: 11.07
+	Hs
		227896 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MYH14_HUMAN (80-569): 1.98e-11: 71.2: 13.69
+	Hs
		228493 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKAP9_HUMAN (45-563): 1.97e-11: 71.2: 13.56
+	Hs
		226691 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MYH11_HUMAN (381-691): 8.22e-09: 62.6: 11.75
+	Hs
		475417 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MYH9_HUMAN (228-774): 4.87e-21: 102: 8.04
+	Hs
		475882 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FKB15_HUMAN (1-294): 8.91e-12: 72.2: 11.07