HitPredict

Interactor 1: KDM1A (O60341)
Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A)
Gene: KDM1A

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Amino_oxidase~Histone
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 852 Hs			1 126
+	Hs
		232087 KDM1A_HUMAN (1-852): 0: 936: 100.00		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		232398 KDM1A_HUMAN (1-852): 0: 936: 100.00		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		232076 KDM1A_HUMAN (1-852): 0: 936: 100.00		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41
+	Hs
		1087268 KDM1B_HUMAN (160-501): 1.3e-62: 228: 24.86		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		918526 KDM1B_HUMAN (160-501): 1.3e-62: 228: 24.86		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		1129833 SMRC1_HUMAN (34-300): 1.41e-57: 216: 16.96		H2B2F_HUMAN (1-126): 2.34e-54: 168: 97.62
+	Hs
		1087279 SMRC2_HUMAN (5-300): 1.17e-57: 216: 15.14		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		1087316 SMRC1_HUMAN (34-300): 1.41e-57: 216: 16.96		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		1251596 SMRC2_HUMAN (5-300): 1.17e-57: 216: 15.14		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		918539 SMRC2_HUMAN (5-300): 1.17e-57: 216: 15.14		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		918577 SMRC1_HUMAN (34-300): 1.41e-57: 216: 16.96		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707692 SMRC2_HUMAN (5-300): 1.17e-57: 216: 15.14		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		886169 SMRC1_HUMAN (34-300): 1.41e-57: 216: 16.96		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41
+	Hs
		1272926 SMRC1_HUMAN (34-300): 1.41e-57: 216: 16.96		H2B1L_HUMAN (1-126): 2.49e-52: 162: 97.62