Protein: LSM2
LSM complex subunit LSM2 (Small nuclear ribonucleoprotein D homolog SNP3)

Gene: LSM2
Organism: Saccharomyces cerevisiae S288C
Interactions: 186
UniProt ID: P38203

Gene Ontology (top 5):
GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0000398 - mRNA splicing, via spliceosome
GO:0000932 - P-body
GO:0003723 - RNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

795885

LSM1
LSM1-LSM7 complex subunit LSM1

14

20

Small-scale

0.983

High

795909

LSM3
LSM complex subunit LSM3

12

20

Small-scale

0.980

High

678669

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

11

5

Small-scale

0.979

High

795887

LSM8
LSM2-LSM8 complex subunit LSM8

9

20

Small-scale

0.974

High

795905

LSM7
LSM complex subunit LSM7

7

20

Small-scale

0.967

High

795875

LSM5
LSM complex subunit LSM5

7

7

Small-scale

0.965

High

795874

LSM4
LSM complex subunit LSM4

6

14

Small-scale

0.955

High

795927

LSM6
LSM complex subunit LSM6

6

20

Small-scale

0.945

High

795893

SART3
U4/U6 snRNA-associated-splicing factor PRP24

5

4

Small-scale

0.925

High

795926

SMD2
Small nuclear ribonucleoprotein Sm D2

5

11

Small-scale

0.922

High

751728

PRP8
Pre-mRNA-splicing factor 8

4

7

Small-scale

0.892

High

780173

SN114
Pre-mRNA-splicing factor SNU114

3

11

High-throughput

0.855

High

795872

RSMB
Small nuclear ribonucleoprotein-associated protein B

3

16

High-throughput

0.847

High

795917

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

2

7

High-throughput

0.789

High

795915

SMD1
Small nuclear ribonucleoprotein Sm D1

2

7

High-throughput

0.776

High

394485

EF1A
Elongation factor 1-alpha

2

1

Small-scale

0.767

High

795883

SMD3
Small nuclear ribonucleoprotein Sm D3

2

16

Small-scale

0.754

High

744105

BRR2
Pre-mRNA-splicing helicase BRR2

7

20

Small-scale

0.737

High

795866

DHH1
ATP-dependent RNA helicase DHH1

5

9

High-throughput

0.718

High

645395

XRN1
5'-3' exoribonuclease 1

5

2

High-throughput

0.716

High

627847

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

3

18

High-throughput

0.662

High

795892

PRP31
Pre-mRNA-processing factor 31

3

8

High-throughput

0.662

High

795950

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

3

5

Small-scale

0.656

High

654148

NAA38
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

0

High-throughput

0.622

High

795945

RUXE
Small nuclear ribonucleoprotein E

1

13

Small-scale

0.621

High

795876

RUXG
Small nuclear ribonucleoprotein G

1

20

High-throughput

0.618

High

795908

RUXF
Small nuclear ribonucleoprotein F

1

20

High-throughput

0.618

High

678954

NOT1
General negative regulator of transcription subunit 1

2

1

High-throughput

0.613

High

625002

PRP6
Pre-mRNA-splicing factor 6

2

15

High-throughput

0.611

High

795912

PRP38
Pre-mRNA-splicing factor 38

2

1

High-throughput

0.611

High

795953

DCP1
mRNA-decapping enzyme subunit 1

2

1

Small-scale

0.600

High

737709

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

2

High-throughput

0.587

High

721604

RENT1
ATP-dependent helicase NAM7

2

2

Small-scale

0.586

High

795888

MTR3
Exosome complex component MTR3

2

0

High-throughput

0.577

High

740896

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

8

High-throughput

0.541

High

403483

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

2

High-throughput

0.536

High

795934

BUD20
Bud site selection protein 20

1

2

High-throughput

0.536

High

438292

NOT3
General negative regulator of transcription subunit 3

1

0

High-throughput

0.518

High

452503

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.513

High

154158

RL36B
Large ribosomal subunit protein eL36B

1

1

High-throughput

0.508

High

533475

RAD18
Postreplication repair E3 ubiquitin-protein ligase RAD18

1

3

High-throughput

0.508

High

666589

DBP1
ATP-dependent RNA helicase DBP1

1

6

High-throughput

0.508

High

746487

BEM3
GTPase-activating protein BEM3

1

4

High-throughput

0.508

High

795864

SSN3
Meiotic mRNA stability protein kinase SSN3

1

3

High-throughput

0.508

High

795868

SWD1
COMPASS component SWD1

1

20

High-throughput

0.508

High

795870

EDC3
Enhancer of mRNA-decapping protein 3

1

2

High-throughput

0.508

High

795899

DCP2
m7GpppN-mRNA hydrolase

1

1

High-throughput

0.508

High

795918

DOT1
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.508

High

795935

ULS1
ATP-dependent helicase ULS1

1

2

High-throughput

0.508

High

795947

GYP5
GTPase-activating protein GYP5

1

2

High-throughput

0.508

High

795951

AIR2
Protein AIR2

1

1

High-throughput

0.508

High

795882

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.500

High

553915

WHI2
Growth regulation protein

1

0

High-throughput

0.486

High

636925

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

High-throughput

0.486

High

639553

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

0

High-throughput

0.486

High

746513

HFA1
Acetyl-CoA carboxylase, mitochondrial

1

0

High-throughput

0.486

High

757981

SEF1
Putative transcription factor SEF1

1

0

High-throughput

0.486

High

795879

CSM2
Chromosome segregation in meiosis protein 2

1

0

High-throughput

0.486

High

795895

YGT5
Putative 2-hydroxyacid dehydrogenase YGL185C

1

0

High-throughput

0.486

High

795902

PDR17
Phosphatidylinositol transfer protein PDR17

1

0

High-throughput

0.486

High

795929

GDE
Glycogen debranching enzyme

1

0

High-throughput

0.486

High

795937

SRO7
Lethal(2) giant larvae protein homolog SRO7

1

0

High-throughput

0.486

High

795942

TPT1
tRNA 2'-phosphotransferase

1

0

High-throughput

0.486

High

795943

YL126
Putative glutamine amidotransferase YLR126C

1

0

High-throughput

0.486

High

757319

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

1

Small-scale

0.481

High

386681

TBB
Tubulin beta chain

1

0

High-throughput

0.479

High

416421

HXKA
Hexokinase-1

1

0

High-throughput

0.479

High

486147

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.479

High

795886

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.479

High

795910

ACT
Actin

1

0

High-throughput

0.479

High

433599

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.479

High

453941

IF4E
Eukaryotic translation initiation factor 4E

1

1

Small-scale

0.479

High

579272

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.479

High

674578

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

677365

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

689411

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

706900

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

738836

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

3

High-throughput

0.479

High

743758

RML2
Large ribosomal subunit protein uL2m

1

1

High-throughput

0.479

High

783920

RM07
Large ribosomal subunit protein uL5m

1

2

High-throughput

0.479

High

795884

SCD6
Protein SCD6

1

3

Small-scale

0.479

High

795907

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.479

High

795919

RM34
Large ribosomal subunit protein bL34m

1

1

High-throughput

0.479

High

795920

RM01
Large ribosomal subunit protein uL1m

1

2

High-throughput

0.479

High

795928

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

6

Small-scale

0.479

High

795930

MHR1
Large ribosomal subunit protein mL67

1

1

High-throughput

0.479

High

795932

DIB1
Spliceosomal protein DIB1

1

4

High-throughput

0.479

High

795933

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

795940

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

795941

YRA1
RNA annealing protein YRA1

1

5

Small-scale

0.479

High

795944

CLF1
Pre-mRNA-splicing factor CLF1

1

20

Small-scale

0.479

High

795946

UTP23
rRNA-processing protein UTP23

1

1

High-throughput

0.479

High

503482

RS28B
Small ribosomal subunit protein eS28B

1

3

High-throughput

0.464

High

732132

COPG
Coatomer subunit gamma

1

1

High-throughput

0.464

High

795949

DCN1
Defective in cullin neddylation protein 1

1

2

High-throughput

0.464

High

632080

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

Small-scale

0.460

High

149721

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

410085

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

435040

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

455022

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

747814

SMY2
Protein SMY2

1

0

Small-scale

0.458

High

795862

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

795890

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

795913

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

795936

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

795938

NMD4
Nonsense-mediated decay protein 4

1

0

Small-scale

0.458

High

795863

YHS2
MIP18 family protein YHR122W

1

2

High-throughput

0.457

High

367008

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.457

High

452891

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.457

High

523726

HSP71
Heat shock protein SSA1

1

5

High-throughput

0.445

High

544617

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

684697

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.445

High

739132

PRP19
Pre-mRNA-processing factor 19

1

18

Small-scale

0.445

High

741439

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.445

High

752178

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

795865

CAJ1
Protein CAJ1

1

2

High-throughput

0.445

High

795869

HSP7E
Heat shock protein SSC3, mitochondrial

1

5

High-throughput

0.445

High

795871

NUG1
Nuclear GTP-binding protein NUG1

1

1

High-throughput

0.445

High

795891

RL4B
Large ribosomal subunit protein uL4B

1

2

High-throughput

0.445

High

795901

NOG2
Nucleolar GTP-binding protein 2

1

1

High-throughput

0.445

High

795921

ERB1
Ribosome biogenesis protein ERB1

1

9

High-throughput

0.445

High

795924

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

7

High-throughput

0.445

High

795954

RS28A
Small ribosomal subunit protein eS28A

1

3

High-throughput

0.439

High

554604

RM02
Large ribosomal subunit protein bL27m

1

1

High-throughput

0.437

High

569495

RM31
Large ribosomal subunit protein mL60

1

1

High-throughput

0.437

High

628156

RM33
Large ribosomal subunit protein uL30m

1

1

High-throughput

0.437

High

647914

RM08
Large ribosomal subunit protein bL17m

1

1

High-throughput

0.437

High

647983

RM20
Large ribosomal subunit protein mL58

1

1

High-throughput

0.437

High

657445

RM25
Large ribosomal subunit protein mL59

1

1

High-throughput

0.437

High

672540

RM32
Large ribosomal subunit protein bL32m

1

1

High-throughput

0.437

High

678179

IMG1
Large ribosomal subunit protein bL19m

1

1

High-throughput

0.437

High

678595

IMG2
Large ribosomal subunit protein mL49

1

1

High-throughput

0.437

High

725720

RM09
Large ribosomal subunit protein uL3m

1

1

High-throughput

0.437

High

736251

RM41
Large ribosomal subunit protein uL23m

1

1

High-throughput

0.437

High

736342

RM49
Large ribosomal subunit protein mL61

1

1

High-throughput

0.437

High

747228

RM06
Large ribosomal subunit protein uL6m

1

2

High-throughput

0.437

High

747320

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

778211

RM38
Large ribosomal subunit protein uL14m

1

1

High-throughput

0.437

High

783785

RM03
Large ribosomal subunit protein mL44

1

1

High-throughput

0.437

High

783851

RM04
Large ribosomal subunit protein uL29m

1

1

High-throughput

0.437

High

783977

RM10
Large ribosomal subunit protein uL15m

1

1

High-throughput

0.437

High

784043

RM11
Large ribosomal subunit protein uL10m

1

1

High-throughput

0.437

High

784092

RM15
Large ribosomal subunit protein mL57

1

1

High-throughput

0.437

High

784158

RM24
Large ribosomal subunit protein bL28m

1

1

High-throughput

0.437

High

784210

RM27
Large ribosomal subunit protein mL41

1

1

High-throughput

0.437

High

784248

RM28
Large ribosomal subunit protein mL40

1

1

High-throughput

0.437

High

784306

RM17
Large ribosomal subunit protein mL46

1

1

High-throughput

0.437

High

784377

RM36
Large ribosomal subunit protein bL31m

1

1

High-throughput

0.437

High

784421

RM37
Large ribosomal subunit protein mL54

1

1

High-throughput

0.437

High

784449

RM39
Large ribosomal subunit protein bL33m

1

1

High-throughput

0.437

High

784478

RM40
Large ribosomal subunit protein uL24m

1

1

High-throughput

0.437

High

792605

RM16
Large ribosomal subunit protein uL16m

1

1

High-throughput

0.437

High

795867

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

795881

RN49
Large ribosomal subunit protein bL21m

1

1

High-throughput

0.437

High

795894

RL4P
Large ribosomal subunit protein uL4m

1

1

High-throughput

0.437

High

795896

MNP1
Large ribosomal subunit protein bL12m

1

1

High-throughput

0.437

High

795897

EIF2A
Eukaryotic translation initiation factor 2A

1

2

High-throughput

0.437

High

795900

RM50
Large ribosomal subunit protein bL9m

1

1

High-throughput

0.437

High

795903

RM19
Large ribosomal subunit protein uL11m

1

1

High-throughput

0.437

High

795904

RM22
Large ribosomal subunit protein uL22m

1

1

High-throughput

0.437

High

795906

RN35
Large ribosomal subunit protein bL35m

1

1

High-throughput

0.437

High

795914

RM13
Large ribosomal subunit protein mL50

1

1

High-throughput

0.437

High

795916

ATP25
ATPase synthesis protein 25, mitochondrial

1

1

High-throughput

0.437

High

795925

RM51
Large ribosomal subunit protein mL43

1

1

High-throughput

0.437

High

795931

RM35
Large ribosomal subunit protein mL38

1

1

High-throughput

0.437

High

795952

RM23
Large ribosomal subunit protein uL13m

1

1

High-throughput

0.437

High

795889

HLJ1
Protein HLJ1

1

1

High-throughput

0.407

High

795948

RPN6
26S proteasome regulatory subunit RPN6

1

0

High-throughput

0.279

Low

734325

YPS1
Aspartic proteinase 3

1

0

High-throughput

0.265

Low

743575

PT127
Putative mitochondrial translation system component PET127

1

0

High-throughput

0.265

Low

795878

RIC1
Guanine nucleotide exchange factor subunit RIC1

1

0

High-throughput

0.265

Low

795880

ATC7
Phospholipid-transporting ATPase NEO1

1

0

High-throughput

0.265

Low

795898

PEX8
Peroxisomal biogenesis factor 8

1

0

High-throughput

0.265

Low

795911

SEC5
Exocyst complex component SEC5

1

0

High-throughput

0.265

Low

795922

SOV1
Protein SOV1, mitochondrial

1

0

High-throughput

0.265

Low

795923

BCH1
Protein BCH1

1

0

High-throughput

0.265

Low

405079

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.261

Low

408570

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low

585549

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.261

Low

661618

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.261

Low

673498

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

0

High-throughput

0.261

Low

795877

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.261

Low

506497

YO163
Putative uncharacterized transporter YOL163W

1

0

High-throughput

0.251

Low

383664

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

795873

MRX1
MIOREX complex component 1

1

0

High-throughput

0.249

Low

795939

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025