HitPredict

Interactor 1: PHLP1 (O60346)
PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)
Gene: PHLPP1

Interactor 2: SYEP (P07814)
Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)]
Gene: EPRS1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33397691
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1717 Hs			1 1512
+	Hs
		430976 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		SYEP_HUMAN (1-1512): 0: 1810: 100.00
+	Hs
		232781 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		SYWC_HUMAN (751-804): 5.49e-09: 62.4: 51.72
+	Hs
		814467 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		SYQ_HUMAN (159-704): 0: 631: 31.19
+	Hs
		643757 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		SYTC_HUMAN (703-1410): 0: 573: 15.62
+	Ce
		247887 LAP1_CAEEL (899-1163): 8.57e-14: 78.6: 29.74		SYQ_CAEEL (153-699): 0: 587: 30.62
+	Hs
		1130541 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		SYTM_HUMAN (774-1411): 7.77e-150: 476: 14.87
+	Hs
		1126900 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		SYEM_HUMAN (198-487): 4.99e-64: 229: 21.75
+	Hs
		616059 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		SYWC_HUMAN (751-804): 5.49e-09: 62.4: 51.72