Protein: AAK1
AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)

Gene: AAK1
Organism: Homo sapiens
Interactions: 113
UniProt ID: Q2M2I8

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005112 - Notch binding
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1178789

WNK1
Serine/threonine-protein kinase WNK1

2

19

High-throughput

0.789

High

1178783

AP2M1
AP-2 complex subunit mu

7

11

High-throughput

0.750

High

988981

AP2B1
AP-2 complex subunit beta

5

19

High-throughput

0.718

High

922580

AP2S1
AP-2 complex subunit sigma

5

10

High-throughput

0.716

High

1145863

RBP1
RalA-binding protein 1

4

14

High-throughput

0.699

High

171712

GAK
Cyclin-G-associated kinase

1

18

High-throughput

0.691

High

1115695

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.691

High

1158791

KCC4
Calcium/calmodulin-dependent protein kinase type IV

1

15

High-throughput

0.691

High

1178770

TLK2
Serine/threonine-protein kinase tousled-like 2

1

19

High-throughput

0.691

High

1178793

ANLN
Anillin

1

5

High-throughput

0.691

High

1178801

WNK2
Serine/threonine-protein kinase WNK2

1

19

High-throughput

0.691

High

1178784

REPS1
RalBP1-associated Eps domain-containing protein 1

4

15

High-throughput

0.691

High

1178762

RUN3A
RUN domain-containing protein 3A

3

1

High-throughput

0.667

High

1156102

ZYX
Zyxin

3

8

High-throughput

0.633

High

1178795

RBM12
RNA-binding protein 12

1

7

High-throughput

0.618

High

318796

RHBT1
Rho-related BTB domain-containing protein 1

1

20

High-throughput

0.618

High

400911

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.618

High

412020

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

1178768

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

344703

AP2A1
AP-2 complex subunit alpha-1

2

20

High-throughput

0.611

High

483341

CLCB
Clathrin light chain B

2

7

High-throughput

0.611

High

535127

BIP
Endoplasmic reticulum chaperone BiP

2

11

High-throughput

0.611

High

1083243

AP1B1
AP-1 complex subunit beta-1

2

20

High-throughput

0.611

High

1143137

PLEC
Plectin

2

15

High-throughput

0.584

High

1178792

AT132
Polyamine-transporting ATPase 13A2

1

9

Small-scale

0.582

High

1178760

AAK1
AP2-associated protein kinase 1

1

17

Small-scale

0.575

High

1178767

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.575

High

396225

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1178766

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

2

2

High-throughput

0.558

High

1178775

FBXL6
F-box/LRR-repeat protein 6

1

5

High-throughput

0.553

High

132853

ODPX
Pyruvate dehydrogenase protein X component, mitochondrial

1

1

High-throughput

0.536

High

347061

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.536

High

568648

GYS1
Glycogen [starch] synthase, muscle

1

3

High-throughput

0.536

High

709126

TPP2
Tripeptidyl-peptidase 2

1

3

High-throughput

0.536

High

906529

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

3

High-throughput

0.536

High

915098

CAZA1
F-actin-capping protein subunit alpha-1

1

6

High-throughput

0.536

High

920816

ACLY
ATP-citrate synthase

1

1

High-throughput

0.536

High

933651

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

4

High-throughput

0.536

High

992777

RACK1
Small ribosomal subunit protein RACK1

1

11

High-throughput

0.536

High

1026060

CLH1
Clathrin heavy chain 1

1

8

High-throughput

0.536

High

1110620

DCTN2
Dynactin subunit 2

1

1

High-throughput

0.536

High

1123918

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

3

High-throughput

0.536

High

1178796

NECP2
Adaptin ear-binding coat-associated protein 2

1

1

High-throughput

0.536

High

1178797

GTSE1
G2 and S phase-expressed protein 1

1

3

High-throughput

0.536

High

106032

APRIO
Alternative prion protein

2

8

High-throughput

0.533

High

1178786

EXOC2
Exocyst complex component 2

1

0

High-throughput

0.513

High

1178790

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.513

High

422212

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

1178791

PAAT
ATPase PAAT

1

2

High-throughput

0.489

High

159672

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

High-throughput

0.479

High

172871

XPO1
Exportin-1

1

15

High-throughput

0.479

High

323727

AP2A2
AP-2 complex subunit alpha-2

1

20

High-throughput

0.479

High

338485

SC24B
Protein transport protein Sec24B

1

5

High-throughput

0.479

High

345894

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

377590

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

2

High-throughput

0.479

High

459611

PROF1
Profilin-1

1

1

High-throughput

0.479

High

474710

VIME
Vimentin

1

11

High-throughput

0.479

High

483107

CLCA
Clathrin light chain A

1

7

High-throughput

0.479

High

529902

TAU
Microtubule-associated protein tau

1

15

High-throughput

0.479

High

552600

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

8

High-throughput

0.479

High

556121

CADH1
Cadherin-1

1

11

High-throughput

0.479

High

642902

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

4

High-throughput

0.479

High

691057

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

714164

PML
Protein PML

1

12

High-throughput

0.479

High

729880

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

730622

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

786635

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

20

High-throughput

0.479

High

791427

SYUA
Alpha-synuclein

1

3

High-throughput

0.479

High

833282

PERI
Peripherin

1

11

High-throughput

0.479

High

889288

NUMB
Protein numb homolog

1

8

High-throughput

0.479

High

896541

VASP
Vasodilator-stimulated phosphoprotein

1

8

High-throughput

0.479

High

966380

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

967770

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

20

High-throughput

0.479

High

971581

1433E
14-3-3 protein epsilon

1

20

High-throughput

0.479

High

982197

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

4

High-throughput

0.479

High

990283

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

1049342

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1178761

GRDN
Girdin

1

15

High-throughput

0.479

High

1178771

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

1178777

REPS2
RalBP1-associated Eps domain-containing protein 2

1

11

High-throughput

0.479

High

1178779

BICD2
Protein bicaudal D homolog 2

1

14

High-throughput

0.479

High

1178780

STON2
Stonin-2

1

11

High-throughput

0.479

High

1178781

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

8

High-throughput

0.479

High

1178782

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

20

High-throughput

0.479

High

1178785

BICD1
Protein bicaudal D homolog 1

1

15

High-throughput

0.479

High

1178798

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

213611

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.458

High

1178776

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1178778

URGCP
Up-regulator of cell proliferation

1

0

High-throughput

0.458

High

1178787

NUP88
Nuclear pore complex protein Nup88

1

0

High-throughput

0.458

High

1178794

I17RB
Interleukin-17 receptor B

1

0

Small-scale

0.458

High

404812

PRIO
Major prion protein

1

1

High-throughput

0.445

High

537251

HSP7C
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.445

High

952192

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

3

High-throughput

0.445

High

1178765

A16L1
Autophagy-related protein 16-1

1

11

High-throughput

0.445

High

341584

EYA4
Protein phosphatase EYA4

1

6

High-throughput

0.437

High

372172

MYC
Myc proto-oncogene protein

1

17

High-throughput

0.437

High

588826

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.437

High

695598

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.437

High

768324

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.437

High

834121

IPP2
Protein phosphatase inhibitor 2

1

2

High-throughput

0.437

High

991853

DYLT1
Dynein light chain Tctex-type 1

1

2

High-throughput

0.437

High

1178128

QSER1
Glutamine and serine-rich protein 1

1

4

High-throughput

0.437

High

1178769

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.437

High

1178772

LUZP1
Leucine zipper protein 1

1

19

High-throughput

0.437

High

1178773

HOOK3
Protein Hook homolog 3

1

14

High-throughput

0.437

High

1178788

ERP44
Endoplasmic reticulum resident protein 44

1

2

High-throughput

0.437

High

1178799

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

1

1

High-throughput

0.437

High

1178774

RYBP
RING1 and YY1-binding protein

1

3

High-throughput

0.407

High

1178763

RM02
Large ribosomal subunit protein uL2m

1

0

High-throughput

0.279

Low

1178800

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

0

High-throughput

0.279

Low

1178764

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025