HitPredict

Interactor 1: ILK (O55222)
Scaffold protein ILK (ILK-1) (ILK-2) (Inactive integrin-linked kinase) (p59ILK)
Gene: ILK

Interactor 2: LIMS1 (Q99JW4)
LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1)
Gene: LIMS1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.918

Property	Details
Experiments	12432066, 28546219, 20164304, 23612611, 19829382
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~LIM
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007229 - integrin-mediated signaling pathway GO:0061351 - neural precursor cell proliferation GO:2000178 - negative regulation of neural precursor cell proliferation
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 452 Mm			1 325
+	Hs
		870124 ILK_HUMAN (1-452): 7.38e-143: 417: 99.56		LIMS1_HUMAN (1-325): 2.87e-85: 261: 99.39
+	Hs
		1104429 ILK_HUMAN (1-452): 7.38e-143: 417: 99.56		LIMS2_HUMAN (1-308): 1.12e-83: 258: 86.36
+	Hs
		104037 ILK_HUMAN (1-452): 7.38e-143: 417: 99.56		F5GZ78_HUMAN (2-189): 2.98e-48: 172: 30.16
+	Mm
		237381 ILK_MOUSE (1-452): 2.66e-142: 416: 100.00		PAXI_MOUSE (2-189): 1.25e-48: 173: 30.16
+	Rn
		1226352 ILK_RAT (1-452): 2.66e-142: 416: 100.00		PAXI_RAT (2-189): 1.61e-48: 172: 30.16
+	Hs
		878448 ILK_HUMAN (1-452): 7.38e-143: 417: 99.56		PAXI_HUMAN (2-189): 8.19e-48: 170: 30.16
+	Hs
		253949 ILK_HUMAN (1-452): 7.38e-143: 417: 99.56		LPXN_HUMAN (2-190): 2.54e-42: 152: 27.37
+	Hs
		1104459 ILK_HUMAN (1-452): 7.38e-143: 417: 99.56		PDLI5_HUMAN (2-124): 1.89e-32: 128: 26.40
+	Ce
		895855 ILKH_CAEEL (1-450): 7.1e-135: 397: 56.44		UNC97_CAEEL (134-320): 6.8e-27: 110: 23.47
+	Hs
		557175 SRC_HUMAN (173-448): 2.05e-103: 319: 24.56		PAXI_HUMAN (2-189): 8.19e-48: 170: 30.16
+	Dm
		1304143 Q9V400_DROME (1-451): 8.91e-135: 397: 57.68		Q8INR0_DROME (3-124): 3e-20: 91.6: 28.46
+	Hs
		463023 YES_HUMAN (176-448): 9.89e-103: 318: 26.60		PAXI_HUMAN (2-189): 8.19e-48: 170: 30.16
+	Ce
		113316 ILKH_CAEEL (1-450): 7.1e-135: 397: 56.44		G5EFG1_CAEEL (191-302): 7.4e-13: 71.2: 33.33
+	Hs
		117131 J3QRU1_HUMAN (176-448): 1.14e-102: 318: 26.60		PDLI7_HUMAN (191-324): 1.39e-36: 138: 29.85
+	Hs
		463235 YES_HUMAN (176-448): 9.89e-103: 318: 26.60		PDLI7_HUMAN (191-324): 1.39e-36: 138: 29.85
+	Hs
		270702 SRC_HUMAN (173-448): 2.05e-103: 319: 24.56		LDB3_HUMAN (2-65): 3.04e-14: 75.4: 25.00