HitPredict

Interactor 1: HCN1 (O60741)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1)
Gene: HCN1

Interactor 2: BRSK1 (Q8TDC3)
Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1)
Gene: BRSK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.80	0.514

Property	Details
Experiments	37207277
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Pkinase~cNMP_binding
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 890 Hs			1 778
+	Hs
		239795 HCN1_HUMAN (1-890): 0: 684: 100.00		MARK3_HUMAN (11-711): 5.7e-165: 497: 26.98
+	Mm
		292130 HCN1_MOUSE (1-890): 0: 651: 90.35		BRSK2_MOUSE (25-778): 1.73e-174: 520: 71.15
+	Hs
		240062 HCN1_HUMAN (1-890): 0: 684: 100.00		MARK2_HUMAN (9-711): 3.43e-154: 470: 27.45
+	Hs
		240226 HCN1_HUMAN (1-890): 0: 684: 100.00		MARK1_HUMAN (4-711): 2.2e-149: 458: 26.05
+	Rn
		812708 HCN1_RAT (1-890): 0: 657: 91.14		AKT1_RAT (6-355): 2.37e-143: 431: 26.18
+	At
		1105373 CNG13_ARATH (95-670): 4.53e-153: 468: 16.52		KIN10_ARATH (33-391): 1.04e-157: 470: 42.31
+	At
		955231 CNG13_ARATH (95-670): 4.53e-153: 468: 16.52		KIN11_ARATH (33-400): 6.72e-152: 455: 40.00
+	At
		955232 CNG18_ARATH (125-699): 1.6e-140: 435: 16.05		KIN11_ARATH (33-400): 6.72e-152: 455: 40.00