Protein: SH2D3
SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1)

Gene: SH2D3, SH2D3C
Organism: Homo sapiens
Interactions: 172
UniProt ID: Q8N5H7

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0007254 - JNK cascade
GO:0007264 - small GTPase-mediated signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

363567

EGFR
Epidermal growth factor receptor

4

20

High-throughput

0.887

High

942744

BCAR1
Breast cancer anti-estrogen resistance protein 1

3

20

Small-scale

0.886

High

211990

EFS
Embryonal Fyn-associated substrate

2

20

High-throughput

0.702

High

522697

PTPRF
Receptor-type tyrosine-protein phosphatase F

2

20

High-throughput

0.659

High

410943

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

1145751

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

472096

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.619

High

532089

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.619

High

463650

LYN
Tyrosine-protein kinase Lyn

1

19

Small-scale

0.618

High

1127358

CASL
Enhancer of filamentation 1

1

20

Small-scale

0.618

High

1155366

RB11B
Ras-related protein Rab-11B

1

15

High-throughput

0.618

High

1327762

SH2D3
SH2 domain-containing protein 3C

1

19

High-throughput

0.618

High

641626

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.579

High

123410

BACH
Cytosolic acyl coenzyme A thioester hydrolase

2

2

High-throughput

0.571

High

135276

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

2

20

High-throughput

0.571

High

399997

CATA
Catalase

2

1

High-throughput

0.571

High

415717

HSPB1
Heat shock protein beta-1

2

9

High-throughput

0.571

High

425569

ISG15
Ubiquitin-like protein ISG15

2

13

High-throughput

0.571

High

442401

GELS
Gelsolin

2

15

High-throughput

0.571

High

456794

ANXA2
Annexin A2

2

11

High-throughput

0.571

High

479845

GSTP1
Glutathione S-transferase P

2

4

High-throughput

0.571

High

542796

G6PD
Glucose-6-phosphate 1-dehydrogenase

2

1

High-throughput

0.571

High

549640

PRPS2
Ribose-phosphate pyrophosphokinase 2

2

16

High-throughput

0.571

High

582879

EZRI
Ezrin

2

20

High-throughput

0.571

High

584872

NQO1
NAD(P)H dehydrogenase [quinone] 1

2

1

High-throughput

0.571

High

647601

UBA1
Ubiquitin-like modifier-activating enzyme 1

2

1

High-throughput

0.571

High

679209

DNJB1
DnaJ homolog subfamily B member 1

2

8

High-throughput

0.571

High

702137

ITPI2
Protein ITPRID2

2

2

High-throughput

0.571

High

732357

PRDX2
Peroxiredoxin-2

2

4

High-throughput

0.571

High

807498

IF4A3
Eukaryotic initiation factor 4A-III

2

12

High-throughput

0.571

High

912585

GDIR1
Rho GDP-dissociation inhibitor 1

2

1

High-throughput

0.571

High

954538

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

16

High-throughput

0.571

High

966611

1433G
14-3-3 protein gamma

2

20

High-throughput

0.571

High

986566

PPIA
Peptidyl-prolyl cis-trans isomerase A

2

10

High-throughput

0.571

High

990499

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.571

High

997033

TBA4A
Tubulin alpha-4A chain

2

20

High-throughput

0.571

High

998155

PA1B2
Platelet-activating factor acetylhydrolase IB subunit alpha2

2

2

High-throughput

0.571

High

1007846

GSTO1
Glutathione S-transferase omega-1

2

4

High-throughput

0.571

High

1029517

SRSF2
Serine/arginine-rich splicing factor 2

2

11

High-throughput

0.571

High

1039968

AKA12
A-kinase anchor protein 12

2

18

High-throughput

0.571

High

1064889

PPID
Peptidyl-prolyl cis-trans isomerase D

2

6

High-throughput

0.571

High

1086878

CDC20
Cell division cycle protein 20 homolog

2

5

High-throughput

0.571

High

1090785

TRAF2
TNF receptor-associated factor 2

2

20

High-throughput

0.571

High

1110502

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

2

12

High-throughput

0.571

High

1116676

RIN1
Ras and Rab interactor 1

2

20

High-throughput

0.571

High

1116967

CD166
CD166 antigen

2

18

High-throughput

0.571

High

1120054

COTL1
Coactosin-like protein

2

4

High-throughput

0.571

High

1142449

PA1B3
Platelet-activating factor acetylhydrolase IB subunit alpha1

2

2

High-throughput

0.571

High

1144074

TEBP
Prostaglandin E synthase 3

2

2

High-throughput

0.571

High

1151583

TRIP6
Thyroid receptor-interacting protein 6

2

20

High-throughput

0.571

High

1154871

NEDD8
Ubiquitin-like protein NEDD8

2

5

High-throughput

0.571

High

1193344

GLYR1
Cytokine-like nuclear factor N-PAC

2

4

High-throughput

0.571

High

1219690

CARL1
F-actin-uncapping protein LRRC16A

2

6

High-throughput

0.571

High

1257916

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

2

15

High-throughput

0.571

High

1294086

DDX42
ATP-dependent RNA helicase DDX42

2

6

High-throughput

0.571

High

1327764

DHB11
Estradiol 17-beta-dehydrogenase 11

2

1

High-throughput

0.571

High

1327769

GEMI5
Gem-associated protein 5

2

4

High-throughput

0.571

High

1327773

NDRG1
Protein NDRG1

2

1

High-throughput

0.571

High

1327775

LPP
Lipoma-preferred partner

2

20

High-throughput

0.571

High

1327776

EXOC4
Exocyst complex component 4

2

1

High-throughput

0.571

High

1327777

P5CR2
Pyrroline-5-carboxylate reductase 2

2

2

High-throughput

0.571

High

1327779

OTUB1
Ubiquitin thioesterase OTUB1

2

1

High-throughput

0.571

High

1327780

PDLI5
PDZ and LIM domain protein 5

2

20

High-throughput

0.571

High

1327790

OSBL8
Oxysterol-binding protein-related protein 8

2

3

High-throughput

0.571

High

1327803

EHD2
EH domain-containing protein 2

2

9

High-throughput

0.571

High

1327805

RCC2
Protein RCC2

2

6

High-throughput

0.571

High

1327806

VPS29
Vacuolar protein sorting-associated protein 29

2

2

High-throughput

0.571

High

1327807

GRHPR
Glyoxylate reductase/hydroxypyruvate reductase

2

1

High-throughput

0.571

High

1327809

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

2

9

High-throughput

0.571

High

1327815

MYO6
Unconventional myosin-VI

2

16

High-throughput

0.571

High

1327816

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

2

15

High-throughput

0.571

High

1327819

NOC2L
Nucleolar complex protein 2 homolog

2

1

High-throughput

0.571

High

1327820

TLN1
Talin-1

2

20

High-throughput

0.571

High

296063

IDHC
Isocitrate dehydrogenase [NADP] cytoplasmic

2

0

High-throughput

0.547

High

335630

AGM1
Phosphoacetylglucosamine mutase

2

0

High-throughput

0.547

High

365423

PGK1
Phosphoglycerate kinase 1

2

0

High-throughput

0.547

High

553234

KCRB
Creatine kinase B-type

2

0

High-throughput

0.547

High

642254

COMT
Catechol O-methyltransferase

2

0

High-throughput

0.547

High

644527

PUR2
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase

2

0

High-throughput

0.547

High

868094

AL1A3
Retinaldehyde dehydrogenase 3

2

0

High-throughput

0.547

High

937180

ADK
Adenosine kinase

2

0

High-throughput

0.547

High

1122675

TTL12
Tubulin--tyrosine ligase-like protein 12

2

0

High-throughput

0.547

High

1224750

RN213
E3 ubiquitin-protein ligase RNF213

2

0

High-throughput

0.547

High

1239243

ARMC6
Armadillo repeat-containing protein 6

2

0

High-throughput

0.547

High

1294705

DAAF5
Dynein axonemal assembly factor 5

2

0

High-throughput

0.547

High

1307376

RIOX2
Ribosomal oxygenase 2

2

0

High-throughput

0.547

High

1327781

GMPPA
Mannose-1-phosphate guanylyltransferase regulatory subunit alpha

2

0

High-throughput

0.547

High

1327782

ABHEB
Putative protein-lysine deacylase ABHD14B

2

0

High-throughput

0.547

High

1327798

SYFB
Phenylalanine--tRNA ligase beta subunit

2

0

High-throughput

0.547

High

1327811

NB5R1
NADH-cytochrome b5 reductase 1

2

0

High-throughput

0.547

High

1327817

HPS5
BLOC-2 complex member HPS5

2

0

High-throughput

0.547

High

1327818

RRP44
Exosome complex exonuclease RRP44

2

0

High-throughput

0.547

High

1327822

SERC
Phosphoserine aminotransferase

2

0

High-throughput

0.547

High

520202

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

909097

NEK4
Serine/threonine-protein kinase Nek4

1

20

High-throughput

0.536

High

131185

CLIC1
Chloride intracellular channel protein 1

2

4

High-throughput

0.521

High

224747

ACTN4
Alpha-actinin-4

2

13

High-throughput

0.521

High

240106

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

16

High-throughput

0.521

High

279830

CISY
Citrate synthase, mitochondrial

2

3

High-throughput

0.521

High

292173

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

2

11

High-throughput

0.521

High

350613

TXD12
Thioredoxin domain-containing protein 12

2

4

High-throughput

0.521

High

376524

LDLR
Low-density lipoprotein receptor

2

4

High-throughput

0.521

High

520919

HLAC
HLA class I histocompatibility antigen, C alpha chain

2

5

High-throughput

0.521

High

553722

ANXA3
Annexin A3

2

11

High-throughput

0.521

High

666328

THIL
Acetyl-CoA acetyltransferase, mitochondrial

2

1

High-throughput

0.521

High

667367

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

4

High-throughput

0.521

High

733961

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

2

2

High-throughput

0.521

High

878328

MRP
MARCKS-related protein

2

1

High-throughput

0.521

High

894307

CRIP1
Cysteine-rich protein 1

2

20

High-throughput

0.521

High

908423

HDGF
Hepatoma-derived growth factor

2

6

High-throughput

0.521

High

921445

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

2

2

High-throughput

0.521

High

932910

P5CS
Delta-1-pyrroline-5-carboxylate synthase

2

1

High-throughput

0.521

High

1060460

DPOE1
DNA polymerase epsilon catalytic subunit A

2

4

High-throughput

0.521

High

1092787

MALL
MAL-like protein

2

6

High-throughput

0.521

High

1121125

UBE4A
Ubiquitin conjugation factor E4 A

2

5

High-throughput

0.521

High

1127971

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

2

16

High-throughput

0.521

High

1143747

PON2
Serum paraoxonase/arylesterase 2

2

1

High-throughput

0.521

High

1217157

RIF1
Telomere-associated protein RIF1

2

14

High-throughput

0.521

High

1226407

TBC9B
TBC1 domain family member 9B

2

5

High-throughput

0.521

High

1252023

TRI72
Tripartite motif-containing protein 72

2

17

High-throughput

0.521

High

1272067

SYPM
Probable proline--tRNA ligase, mitochondrial

2

3

High-throughput

0.521

High

1323099

CCAR2
Cell cycle and apoptosis regulator protein 2

2

3

High-throughput

0.521

High

1327511

SRBD1
S1 RNA-binding domain-containing protein 1

2

1

High-throughput

0.521

High

1327763

S43A3
Equilibrative nucleobase transporter 1

2

2

High-throughput

0.521

High

1327766

COQ8A
Atypical kinase COQ8A, mitochondrial

2

3

High-throughput

0.521

High

1327767

S2540
Mitochondrial glutathione transporter SLC25A40

2

12

High-throughput

0.521

High

1327770

IPO4
Importin-4

2

7

High-throughput

0.521

High

1327772

AP3S1
AP-3 complex subunit sigma-1

2

14

High-throughput

0.521

High

1327783

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

2

2

High-throughput

0.521

High

1327784

UHRF1
E3 ubiquitin-protein ligase UHRF1

2

12

High-throughput

0.521

High

1327785

S29A1
Equilibrative nucleoside transporter 1

2

2

High-throughput

0.521

High

1327789

EIF2A
Eukaryotic translation initiation factor 2A

2

1

High-throughput

0.521

High

1327792

WDR13
WD repeat-containing protein 13

2

5

High-throughput

0.521

High

1327793

AMPB
Aminopeptidase B

2

3

High-throughput

0.521

High

1327794

GRPE1
GrpE protein homolog 1, mitochondrial

2

2

High-throughput

0.521

High

1327797

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

2

1

High-throughput

0.521

High

1327799

TM14B
Transmembrane protein 14B

2

1

High-throughput

0.521

High

1327801

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

2

3

High-throughput

0.521

High

1327804

STIM2
Stromal interaction molecule 2

2

1

High-throughput

0.521

High

1327808

WNT16
Protein Wnt-16

2

1

High-throughput

0.521

High

1327810

DPP2
Dipeptidyl peptidase 2

2

1

High-throughput

0.521

High

1327812

ATIF1
ATPase inhibitor, mitochondrial

2

1

High-throughput

0.521

High

1327813

TF3C4
General transcription factor 3C polypeptide 4

2

1

High-throughput

0.521

High

1327814

ACSL5
Long-chain-fatty-acid--CoA ligase 5

2

2

High-throughput

0.521

High

1327821

HYOU1
Hypoxia up-regulated protein 1

2

20

High-throughput

0.521

High

1327824

S4A7
Sodium bicarbonate cotransporter 3

2

3

High-throughput

0.521

High

1327823

SNCAP
Synphilin-1

1

16

High-throughput

0.481

High

1045519

TF65
Transcription factor p65

1

8

High-throughput

0.479

High

1041174

CAV1
Caveolin-1

1

9

Small-scale

0.457

High

1327768

CE192
Centrosomal protein of 192 kDa

1

1

High-throughput

0.445

High

1327795

Q9HCK3
KIAA1569 protein

1

1

High-throughput

0.437

High

66998

AXA2L
Putative annexin A2-like protein

1

11

High-throughput

0.407

High

70010

D11L8
Putative ATP-dependent DNA helicase DDX11-like protein 8

1

1

High-throughput

0.407

High

71632

TM14D
Transmembrane protein 14DP

1

1

High-throughput

0.407

High

380092

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

5

High-throughput

0.407

High

1327774

DDX12
Putative ATP-dependent DNA helicase DDX12

1

1

High-throughput

0.407

High

212077

B4GT5
Beta-1,4-galactosyltransferase 5

2

0

High-throughput

0.298

High

294938

POP7
Ribonuclease P protein subunit p20

2

0

High-throughput

0.298

High

519638

LYAG
Lysosomal alpha-glucosidase

2

0

High-throughput

0.298

High

775689

DEK
Protein DEK

2

0

High-throughput

0.298

High

1315448

K2013
Uncharacterized protein KIAA2013

2

0

High-throughput

0.298

High

1327765

LEMD2
LEM domain-containing protein 2

2

0

High-throughput

0.298

High

1327771

PTCD2
Pentatricopeptide repeat-containing protein 2, mitochondrial

2

0

High-throughput

0.298

High

1327778

TLCD1
TLC domain-containing protein 1

2

0

High-throughput

0.298

High

1327786

CAB45
45 kDa calcium-binding protein

2

0

High-throughput

0.298

High

1327787

TBCD
Tubulin-specific chaperone D

2

0

High-throughput

0.298

High

1327788

HINT2
Adenosine 5'-monophosphoramidase HINT2

2

0

High-throughput

0.298

High

1327791

T126A
Transmembrane protein 126A

2

0

High-throughput

0.298

High

1327796

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

2

0

High-throughput

0.298

High

1327800

CLN6
Ceroid-lipofuscinosis neuronal protein 6

2

0

High-throughput

0.298

High

1327802

CISD1
CDGSH iron-sulfur domain-containing protein 1

2

0

High-throughput

0.298

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025