Protein: TNAP3
Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 2.3.2.-) (EC 3.4.19.12) (OTU domain-containing protein 7C) (Putative DNA-binding protein A20) (Zinc finger protein A20) [Cleaved into: A20p50; A20p37]

Gene: TNAP3, TNFAIP3
Organism: Homo sapiens
Interactions: 187
UniProt ID: P21580

Gene Ontology (top 5):
GO:0001922 - B-1 B cell homeostasis
GO:0002020 - protease binding
GO:0002237 - response to molecule of bacterial origin
GO:0002634 - regulation of germinal center formation
GO:0002677 - negative regulation of chronic inflammatory response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

475332

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

14

11

Small-scale

0.984

High

599612

TNAP3
Tumor necrosis factor alpha-induced protein 3

13

4

Small-scale

0.983

High

474920

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

11

High-throughput

0.811

High

599712

OTUD5
OTU domain-containing protein 5

2

4

High-throughput

0.811

High

599640

RD23A
UV excision repair protein RAD23 homolog A

2

10

High-throughput

0.783

High

599638

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

5

Small-scale

0.778

High

599672

TNIP1
TNFAIP3-interacting protein 1

15

16

Small-scale

0.763

High

599753

TRAF6
TNF receptor-associated factor 6

16

20

Small-scale

0.762

High

599684

TAXB1
Tax1-binding protein 1

11

11

Small-scale

0.758

High

599758

NEMO
NF-kappa-B essential modulator

9

14

Small-scale

0.757

High

599652

TRAF2
TNF receptor-associated factor 2

9

18

Small-scale

0.755

High

599661

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

8

4

Small-scale

0.755

High

352488

TNFA
Tumor necrosis factor

11

3

Small-scale

0.755

High

584312

TNR1A
Tumor necrosis factor receptor superfamily member 1A

7

7

Small-scale

0.740

High

599692

TNIP2
TNFAIP3-interacting protein 2

6

2

Small-scale

0.734

High

599709

RNF31
E3 ubiquitin-protein ligase RNF31

5

9

Small-scale

0.714

High

599650

1433F
14-3-3 protein eta

4

19

Small-scale

0.707

High

599646

1433Z
14-3-3 protein zeta/delta

4

19

Small-scale

0.696

High

599658

BIRC2
Baculoviral IAP repeat-containing protein 2

4

5

Small-scale

0.694

High

158397

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

4

7

Small-scale

0.692

High

599744

TBK1
Serine/threonine-protein kinase TBK1

4

9

Small-scale

0.691

High

599752

RNF11
RING finger protein 11

4

4

Small-scale

0.690

High

599755

RN114
E3 ubiquitin-protein ligase RNF114

3

17

Small-scale

0.683

High

599625

TRI23
E3 ubiquitin-protein ligase TRIM23

3

9

High-throughput

0.675

High

599704

ARRD3
Arrestin domain-containing protein 3

3

3

High-throughput

0.675

High

599621

1433B
14-3-3 protein beta/alpha

3

19

Small-scale

0.674

High

599670

CASP8
Caspase-8

3

6

Small-scale

0.674

High

599683

AN13D
Ankyrin repeat domain-containing protein 13D

3

11

Small-scale

0.669

High

599714

TNIP3
TNFAIP3-interacting protein 3

3

11

Small-scale

0.668

High

599653

TRAF1
TNF receptor-associated factor 1

3

11

Small-scale

0.661

High

599654

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

3

18

Small-scale

0.658

High

599655

FADD
FAS-associated death domain protein

3

11

Small-scale

0.656

High

599642

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

5

Small-scale

0.647

High

599644

1433E
14-3-3 protein epsilon

3

1

Small-scale

0.642

High

599628

MTOR
Serine/threonine-protein kinase mTOR

3

7

Small-scale

0.640

High

599649

TF65
Transcription factor p65

3

8

Small-scale

0.640

High

599643

1433G
14-3-3 protein gamma

2

19

High-throughput

0.639

High

599730

SHRPN
Sharpin

2

2

Small-scale

0.635

High

599633

GSK3B
Glycogen synthase kinase-3 beta

2

4

Small-scale

0.634

High

599717

M3K5
Mitogen-activated protein kinase kinase kinase 5

2

14

Small-scale

0.634

High

522772

SRC
Proto-oncogene tyrosine-protein kinase Src

2

1

High-throughput

0.628

High

599695

SHKB1
SH3KBP1-binding protein 1

2

7

High-throughput

0.628

High

599703

RN166
E3 ubiquitin-protein ligase RNF166

2

17

High-throughput

0.628

High

599705

AIDA
Axin interactor, dorsalization-associated protein

2

1

High-throughput

0.628

High

599715

NED4L
E3 ubiquitin-protein ligase NEDD4-like

2

6

High-throughput

0.628

High

599731

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

2

6

High-throughput

0.628

High

599748

TBC24
TBC1 domain family member 24

2

8

High-throughput

0.628

High

599754

ARI1
E3 ubiquitin-protein ligase ARIH1

2

8

High-throughput

0.628

High

599743

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

2

4

Small-scale

0.624

High

599749

UBQL1
Ubiquilin-1

1

7

Small-scale

0.621

High

599724

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

2

9

Small-scale

0.614

High

599694

LNX1
E3 ubiquitin-protein ligase LNX

2

7

High-throughput

0.606

High

599739

RN216
E3 ubiquitin-protein ligase RNF216

2

7

High-throughput

0.606

High

599662

LAPM5
Lysosomal-associated transmembrane protein 5

2

0

Small-scale

0.605

High

599613

USF1
Upstream stimulatory factor 1

2

3

Small-scale

0.601

High

599666

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

2

12

Small-scale

0.601

High

234780

ACSL4
Long-chain-fatty-acid--CoA ligase 4

2

3

Small-scale

0.584

High

599659

SQSTM
Sequestosome-1

2

6

Small-scale

0.584

High

599664

CUL3
Cullin-3

2

6

Small-scale

0.584

High

330059

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.580

High

571667

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

2

Small-scale

0.573

High

599686

CCD50
Coiled-coil domain-containing protein 50

1

2

Small-scale

0.573

High

326434

SNAI1
Zinc finger protein SNAI1

1

10

Small-scale

0.561

High

569178

CEBPB
CCAAT/enhancer-binding protein beta

1

1

Small-scale

0.561

High

599688

RN168
E3 ubiquitin-protein ligase RNF168

1

3

Small-scale

0.561

High

386086

P53
Cellular tumor antigen p53

2

0

Small-scale

0.559

High

599733

Q9H4D1
Protein kinase

1

9

Small-scale

0.552

High

599706

TIFA
TRAF-interacting protein with FHA domain-containing protein A

1

0

Small-scale

0.537

High

363564

TTHY
Transthyretin

1

1

High-throughput

0.536

High

599614

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

3

High-throughput

0.536

High

599624

MYH11
Myosin-11

1

3

High-throughput

0.536

High

599627

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

4

High-throughput

0.536

High

599630

AFAM
Afamin

1

3

High-throughput

0.536

High

599634

KLK7
Kallikrein-7

1

1

High-throughput

0.536

High

599635

S26A2
Sulfate transporter

1

1

High-throughput

0.536

High

599656

G3BP1
Ras GTPase-activating protein-binding protein 1

1

4

High-throughput

0.536

High

599668

HABP2
Hyaluronan-binding protein 2

1

4

High-throughput

0.536

High

599700

TANK
TRAF family member-associated NF-kappa-B activator

1

1

High-throughput

0.536

High

599708

OPTN
Optineurin

1

19

High-throughput

0.536

High

599740

RCC2
Protein RCC2

1

4

High-throughput

0.536

High

599693

DPTOR
DEP domain-containing mTOR-interacting protein

1

1

Small-scale

0.523

High

167472

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

11

Small-scale

0.515

High

599637

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

Small-scale

0.515

High

599685

TCAM1
TIR domain-containing adapter molecule 1

1

1

Small-scale

0.515

High

599701

IRF7
Interferon regulatory factor 7

1

3

Small-scale

0.515

High

304716

S1PR2
Sphingosine 1-phosphate receptor 2

1

0

High-throughput

0.513

High

599629

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.513

High

599674

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.513

High

599734

AZI2
5-azacytidine-induced protein 2

1

0

High-throughput

0.513

High

599736

SPCS
O-phosphoseryl-tRNA(Sec) selenium transferase

1

0

High-throughput

0.513

High

599675

OCLN
Occludin

1

2

Small-scale

0.512

High

229839

KIF5C
Kinesin heavy chain isoform 5C

1

9

High-throughput

0.489

High

599651

GALT1
Polypeptide N-acetylgalactosaminyltransferase 1

1

1

High-throughput

0.489

High

599677

SDK2
Protein sidekick-2

1

1

High-throughput

0.489

High

599681

LRC69
Leucine-rich repeat-containing protein 69

1

10

High-throughput

0.489

High

599687

SPA12
Serpin A12

1

4

High-throughput

0.489

High

599691

DIK2A
Divergent protein kinase domain 2A

1

1

High-throughput

0.489

High

599699

PCSK5
Proprotein convertase subtilisin/kexin type 5

1

4

High-throughput

0.489

High

599710

MMAB
Corrinoid adenosyltransferase MMAB

1

1

High-throughput

0.489

High

156219

PSA7
Proteasome subunit alpha type-7

1

5

Small-scale

0.481

High

262151

TRIM3
Tripartite motif-containing protein 3

1

10

High-throughput

0.481

High

391328

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

5

Small-scale

0.481

High

542975

FABP4
Fatty acid-binding protein, adipocyte

1

3

Small-scale

0.481

High

599616

1433T
14-3-3 protein theta

1

19

Small-scale

0.481

High

599641

RS20
Small ribosomal subunit protein uS10

1

2

Small-scale

0.481

High

599645

RS15
Small ribosomal subunit protein uS19

1

1

Small-scale

0.481

High

599673

PCBP1
Poly(rC)-binding protein 1

1

8

Small-scale

0.481

High

599698

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.481

High

599718

RNF5
E3 ubiquitin-protein ligase RNF5

1

3

High-throughput

0.481

High

599720

ZN251
Zinc finger protein 251

1

2

Small-scale

0.481

High

599725

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

12

High-throughput

0.481

High

599726

UBXN6
UBX domain-containing protein 6

1

1

Small-scale

0.481

High

599727

TRIM5
Tripartite motif-containing protein 5

1

2

High-throughput

0.481

High

599728

TRIM2
Tripartite motif-containing protein 2

1

10

High-throughput

0.481

High

599738

RNF12
E3 ubiquitin-protein ligase RLIM

1

2

High-throughput

0.481

High

599742

RNF14
E3 ubiquitin-protein ligase RNF14

1

7

High-throughput

0.481

High

121440

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

7

Small-scale

0.479

High

123853

SPT5H
Transcription elongation factor SPT5

1

5

Small-scale

0.479

High

154308

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

8

Small-scale

0.479

High

160379

AURKA
Aurora kinase A

1

6

Small-scale

0.479

High

170601

AXIN1
Axin-1

1

2

Small-scale

0.479

High

197882

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

1

Small-scale

0.479

High

206937

SMAD6
Mothers against decapentaplegic homolog 6

1

2

Small-scale

0.479

High

321873

RIGI
Antiviral innate immune response receptor RIG-I

1

9

Small-scale

0.479

High

431530

HS90A
Heat shock protein HSP 90-alpha

1

4

High-throughput

0.479

High

437891

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.479

High

527949

RINI
Ribonuclease inhibitor

1

4

High-throughput

0.479

High

587412

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

18

Small-scale

0.479

High

599615

GCSP
Glycine dehydrogenase

1

1

High-throughput

0.479

High

599618

GRN
Progranulin

1

1

Small-scale

0.479

High

599619

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

6

High-throughput

0.479

High

599620

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

Small-scale

0.479

High

599622

1433S
14-3-3 protein sigma

1

19

High-throughput

0.479

High

599623

CTNB1
Catenin beta-1

1

8

Small-scale

0.479

High

599626

STAT3
Signal transducer and activator of transcription 3

1

4

Small-scale

0.479

High

599632

AL9A1
4-trimethylaminobutyraldehyde dehydrogenase

1

5

High-throughput

0.479

High

599636

TNF10
Tumor necrosis factor ligand superfamily member 10

1

3

Small-scale

0.479

High

599639

KIF11
Kinesin-like protein KIF11

1

9

High-throughput

0.479

High

599647

GSTO1
Glutathione S-transferase omega-1

1

2

Small-scale

0.479

High

599648

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

16

Small-scale

0.479

High

599657

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

Small-scale

0.479

High

599660

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

6

Small-scale

0.479

High

599663

KRR1
KRR1 small subunit processome component homolog

1

1

Small-scale

0.479

High

599667

BECN1
Beclin-1

1

1

Small-scale

0.479

High

599669

MCM6
DNA replication licensing factor MCM6

1

6

High-throughput

0.479

High

599678

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

6

High-throughput

0.479

High

599679

RICTR
Rapamycin-insensitive companion of mTOR

1

1

Small-scale

0.479

High

599682

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

599689

AN13A
Ankyrin repeat domain-containing protein 13A

1

8

Small-scale

0.479

High

599696

NEK7
Serine/threonine-protein kinase Nek7

1

8

Small-scale

0.479

High

599697

CNKR2
Connector enhancer of kinase suppressor of ras 2

1

3

High-throughput

0.479

High

599713

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

6

Small-scale

0.479

High

599716

TRIB3
Tribbles homolog 3

1

4

Small-scale

0.479

High

599719

VRK1
Serine/threonine-protein kinase VRK1

1

4

High-throughput

0.479

High

599721

RIOK1
Serine/threonine-protein kinase RIO1

1

4

Small-scale

0.479

High

599722

RIOK2
Serine/threonine-protein kinase RIO2

1

4

Small-scale

0.479

High

599723

CAR11
Caspase recruitment domain-containing protein 11

1

6

Small-scale

0.479

High

599735

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

3

Small-scale

0.479

High

599741

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

1

Small-scale

0.479

High

599745

FBX3
F-box only protein 3

1

2

High-throughput

0.479

High

599747

TAOK2
Serine/threonine-protein kinase TAO2

1

11

Small-scale

0.479

High

599751

CSEN
Calsenilin

1

1

Small-scale

0.479

High

599757

STK24
Serine/threonine-protein kinase 24

1

6

Small-scale

0.479

High

599676

Q4G0R1
PIBF1 protein

1

1

High-throughput

0.470

High

358473

CO1A1
Collagen alpha-1(I) chain

1

0

Small-scale

0.460

High

330231

BCL10
B-cell lymphoma/leukemia 10

1

0

Small-scale

0.458

High

599711

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

0

Small-scale

0.458

High

599737

TLR9
Toll-like receptor 9

1

0

Small-scale

0.458

High

599746

PLAT4
Phospholipase A and acyltransferase 4

1

0

Small-scale

0.458

High

599732

WNK1
Serine/threonine-protein kinase WNK1

1

7

High-throughput

0.457

High

66377

A2ML1
Alpha-2-macroglobulin-like protein 1

1

5

High-throughput

0.445

High

484881

ZTRF1
Zinc finger TRAF-type-containing protein 1

1

4

High-throughput

0.445

High

599631

PPCE
Prolyl endopeptidase

1

2

High-throughput

0.445

High

561498

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

2

Small-scale

0.439

High

599665

GIT2
ARF GTPase-activating protein GIT2

1

14

High-throughput

0.439

High

599680

CLC4G
C-type lectin domain family 4 member G

1

2

Small-scale

0.439

High

72277

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

5

High-throughput

0.437

High

599617

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

1

High-throughput

0.437

High

599690

LRC47
Leucine-rich repeat-containing protein 47

1

6

High-throughput

0.437

High

599750

XCT
Cystine/glutamate transporter

1

2

Small-scale

0.437

High

599756

PCDB5
Protocadherin beta-5

2

0

High-throughput

0.328

High

254152

FZD7
Frizzled-7

1

0

High-throughput

0.279

Low

599671

MELT
Ventricular zone-expressed PH domain-containing protein homolog 1

1

0

High-throughput

0.279

Low

599707

PKHB2
Pleckstrin homology domain-containing family B member 2

1

0

High-throughput

0.279

Low

599729

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

0

Small-scale

0.251

Low

599702

NAR4
Ecto-ADP-ribosyltransferase 4

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024