Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.996

The method score is based on:

Property Details
Experiments 25375667, 25527291, 26254304, 25969509, 26631732, 26116755, 28414322, 28276439, 24647965, 29180628, 29987020, 28689991, 27096575, 27312108, 29530980, 29995846, 30446597, 25959826, 32193420, 31432739 and 29 others

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Identification Methods enzymatic study, affinity chromatography technology, pull down, proximity labelling technology, nuclear magnetic resonance, isothermal titration calorimetry
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains IBR_2~ubiquitin, IBR_2~zf-RING_12, IBR_2~zf-RING_14, ubiquitin~ubiquitin, ubiquitin~zf-RING_12, ubiquitin~zf-RING_14, zf-RING_12~zf-RING_12, zf-RING_12~zf-RING_14, zf-RING_14~zf-RING_14
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000139 - Golgi membrane
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0000266 - mitochondrial fission
and 156 others

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Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 465
Hs

1 465
+ Rn
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Dm
+ Hs
+ Zm
+ Hs
+ Hs
+ At
+ Dm
+ Dm
+ Dm

Service provided by Combinatics, Japan

Last updated: 11Aug2025