HitPredict

Interactor 1: HCN1 (O60741)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1)
Gene: HCN1

Interactor 2: EPHA6 (Q9UF33)
Ephrin type-A receptor 6 (EC 2.7.10.1) (EPH homology kinase 2) (EHK-2) (EPH-like kinase 12) (EK12)
Gene: EPHA6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	37207277
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030425 - dendrite
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 890 Hs			1 1036
+	Hs
		240007 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHA7_HUMAN (9-1036): 0: 1192: 55.53
+	Hs
		239877 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHA5_HUMAN (11-1028): 0: 1177: 56.86
+	Hs
		239879 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHA4_HUMAN (15-1036): 0: 1176: 56.88
+	Hs
		239797 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHA3_HUMAN (24-1028): 0: 1168: 59.56
+	Hs
		239878 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHB1_HUMAN (33-1030): 0: 1155: 51.69
+	Hs
		239798 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHB2_HUMAN (34-1036): 0: 1138: 51.33
+	Hs
		239876 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHB3_HUMAN (31-1029): 0: 1088: 51.53
+	Hs
		239956 HCN1_HUMAN (1-890): 0: 684: 100.00		TYRO3_HUMAN (275-1016): 9.43e-147: 462: 20.10
+	Hs
		239707 HCN1_HUMAN (1-890): 0: 684: 100.00		FYN_HUMAN (625-931): 3.77e-59: 214: 37.99
+	Hs
		239747 HCN1_HUMAN (1-890): 0: 684: 100.00		SRC_HUMAN (623-931): 3.42e-59: 214: 40.32
+	Hs
		412401 HCN2_HUMAN (3-812): 0: 576: 63.68		FYN_HUMAN (625-931): 3.77e-59: 214: 37.99
+	Hs
		523195 HCN2_HUMAN (3-812): 0: 576: 63.68		SRC_HUMAN (623-931): 3.42e-59: 214: 40.32
+	Hs
		412422 HCN4_HUMAN (15-885): 3.07e-173: 536: 57.64		FYN_HUMAN (625-931): 3.77e-59: 214: 37.99