HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PSB5 (P28074)
Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X) (Proteasome subunit beta-5) (beta-5)
Gene: PSMB5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35256949, 23503661
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006979 - response to oxidative stress GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 263
+	Hs
		240819 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSA5_HUMAN (28-258): 9.79e-86: 257: 15.64
+	Hs
		242681 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSB7_HUMAN (39-251): 7.53e-82: 248: 25.82
+	Hs
		240794 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSA2_HUMAN (30-259): 3.22e-79: 240: 18.64
+	Hs
		240796 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSA4_HUMAN (32-255): 4.73e-79: 240: 18.22
+	Hs
		240959 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSB10_HUMAN (44-248): 1.25e-77: 237: 27.32
+	Hs
		240821 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSB6_HUMAN (43-245): 6.74e-77: 234: 31.37
+	Hs
		507087 UBB_HUMAN (1-234): 4.43e-61: 200: 17.92		PSA2_HUMAN (30-259): 3.22e-79: 240: 18.64
+	Hs
		507088 UBB_HUMAN (1-234): 4.43e-61: 200: 17.92		PSA4_HUMAN (32-255): 4.73e-79: 240: 18.22
+	Zm
		35458 Q42415_MAIZE (1-153): 6.6e-50: 179: 20.13		A0A1D6LKR2_MAIZE (55-245): 1.82e-69: 215: 27.55
+	At
		307138 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSA4A_ARATH (32-263): 2.53e-85: 256: 17.21
+	At
		1168065 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSB5B_ARATH (5-263): 5.02e-82: 248: 55.56
+	At
		200665 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSB5A_ARATH (5-263): 1.17e-81: 248: 55.17
+	At
		1167666 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSB7B_ARATH (56-248): 2.73e-81: 247: 26.43
+	At
		200652 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSB7A_ARATH (56-248): 4.81e-81: 246: 25.91
+	At
		200646 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSA2A_ARATH (30-259): 1.44e-80: 243: 18.99
+	At
		1167715 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSA2B_ARATH (30-259): 9.09e-80: 242: 18.99
+	At
		1167744 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSB6_ARATH (57-257): 9.71e-73: 224: 26.60
+	Zm
		35457 Q41754_MAIZE (1-76): 1.2e-29: 121: 31.58		A0A1D6LKR2_MAIZE (55-245): 1.82e-69: 215: 27.55