HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PSB10 (P40306)
Proteasome subunit beta type-10 (EC 3.4.25.1) (Low molecular mass protein 10) (Macropain subunit MECl-1) (Multicatalytic endopeptidase complex subunit MECl-1) (Proteasome MECl-1) (Proteasome subunit beta-2i)
Gene: PSMB10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 273
+	Hs
		242681 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSB7_HUMAN (7-272): 1.64e-91: 273: 57.84
+	Hs
		240822 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSB5_HUMAN (27-240): 1.41e-86: 260: 26.98
+	Hs
		240796 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSA4_HUMAN (6-238): 4.46e-85: 256: 21.25
+	Hs
		240819 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSA5_HUMAN (14-219): 6.74e-80: 242: 22.69
+	Hs
		240821 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PSB6_HUMAN (36-225): 2.75e-73: 225: 29.32
+	Hs
		507088 UBB_HUMAN (1-234): 4.43e-61: 200: 17.92		PSA4_HUMAN (6-238): 4.46e-85: 256: 21.25
+	Sc
		509409 UBI4P_YEAST (1-229): 3.44e-60: 203: 18.72		PSA3_YEAST (7-246): 1.04e-80: 245: 20.16
+	At
		307138 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSA4A_ARATH (6-261): 1.15e-89: 267: 19.08
+	At
		1167666 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSB7B_ARATH (6-271): 7.56e-87: 261: 50.37
+	At
		200652 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSB7A_ARATH (6-271): 6.2e-86: 259: 49.44
+	At
		200665 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSB5A_ARATH (38-249): 6.33e-83: 251: 28.64
+	At
		1168065 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSB5B_ARATH (13-225): 1.48e-82: 250: 27.57
+	At
		200646 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSA2A_ARATH (8-238): 2.08e-82: 248: 22.88
+	At
		1167715 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSA2B_ARATH (8-238): 1.82e-81: 246: 23.31
+	At
		1167744 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		PSB6_ARATH (30-224): 2.49e-72: 223: 31.63
+	Zm
		35458 Q42415_MAIZE (1-153): 6.6e-50: 179: 20.13		A0A1D6LKR2_MAIZE (37-223): 6.61e-22: 93.2: 29.69
+	Zm
		35457 Q41754_MAIZE (1-76): 1.2e-29: 121: 31.58		A0A1D6LKR2_MAIZE (37-223): 6.61e-22: 93.2: 29.69