HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ATD3A (Q9NVI7)
ATPase family AAA domain-containing protein 3A (EC 3.6.1.-)
Gene: ATAD3A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35509820, 24244333
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~ubiquitin
Common GO terms	GO:0005739 - mitochondrion GO:0007005 - mitochondrion organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 586
+	Hs
		241209 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		TERA_HUMAN (3-582): 3.92e-137: 420: 15.31
+	Hs
		241925 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		ATD3C_HUMAN (199-586): 5.42e-122: 368: 84.06
+	Hs
		241937 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		ATD3B_HUMAN (41-586): 4.07e-118: 366: 93.41
+	Hs
		241306 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		PRS10_HUMAN (172-574): 1.01e-100: 312: 16.59
+	Hs
		935348 ARI1_HUMAN (163-464): 4.18e-73: 242: 19.67		TERA_HUMAN (3-582): 3.92e-137: 420: 15.31
+	Hs
		243398 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		AFG32_HUMAN (220-575): 7.27e-70: 242: 19.14
+	Hs
		335046 ARI2_HUMAN (222-464): 9.66e-64: 215: 20.82		TERA_HUMAN (3-582): 3.92e-137: 420: 15.31
+	Sc
		509430 UBI4P_YEAST (1-229): 3.44e-60: 203: 18.72		CDC48_YEAST (3-585): 3.73e-137: 420: 16.86
+	Hs
		1310798 CUL9_HUMAN (30-463): 4.64e-78: 267: 18.81		ATD3A_HUMAN (41-586): 7.3e-114: 353: 100.00
+	Hs
		507129 UBB_HUMAN (1-234): 4.43e-61: 200: 17.92		TERA_HUMAN (3-582): 3.92e-137: 420: 15.31
+	Hs
		1214780 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		ATD3B_HUMAN (41-586): 4.07e-118: 366: 93.41
+	At
		1168161 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		CD48E_ARATH (3-585): 1.53e-145: 442: 16.70
+	Hs
		242296 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		AFG2A_HUMAN (2-285): 3.7e-39: 155: 11.85
+	At
		930107 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		CD48A_ARATH (3-585): 3.61e-141: 430: 16.67
+	Hs
		935185 RN19A_HUMAN (236-452): 1.24e-30: 127: 21.62		TERA_HUMAN (3-582): 3.92e-137: 420: 15.31
+	Mm
		897529 RN19A_MOUSE (236-452): 5.01e-30: 125: 21.62		TERA_MOUSE (3-582): 3.92e-137: 420: 15.31
+	Sc
		509663 UBI4P_YEAST (1-229): 3.44e-60: 203: 18.72		PRS10_YEAST (144-573): 6.01e-78: 255: 18.93
+	Hs
		507437 UBB_HUMAN (1-234): 4.43e-61: 200: 17.92		AFG32_HUMAN (220-575): 7.27e-70: 242: 19.14
+	Hs
		188503 CUL9_HUMAN (30-463): 4.64e-78: 267: 18.81		NVL_HUMAN (1-256): 1.25e-35: 144: 10.73
+	Zm
		45145 Q41754_MAIZE (1-76): 1.2e-29: 121: 31.58		A0A1D6QEJ7_MAIZE (308-557): 5.84e-72: 250: 24.71