HitPredict

Interactor 1: BRD4 (O60885)
Bromodomain-containing protein 4 (Protein HUNK1)
Gene: BRD4

Interactor 2: H2B1B (P33778)
Histone H2B type 1-B (H2B-clustered histone 3) (Histone H2B.1) (Histone H2B.f) (H2B/f)
Gene: H2BC3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	27248496, 33567268
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1362 Hs			1 126
+	Hs
		243805 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		H2B1J_HUMAN (1-126): 8.38e-55: 169: 97.62
+	Hs
		244513 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		H2B2E_HUMAN (1-126): 7.04e-55: 169: 98.41
+	Hs
		244752 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		H2B1H_HUMAN (1-126): 6.88e-55: 169: 96.83
+	Hs
		241395 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		H2B1K_HUMAN (1-126): 1.48e-54: 168: 96.83
+	Hs
		244236 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		H2B1C_HUMAN (1-126): 1.27e-54: 168: 97.62
+	Hs
		244660 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		H2B3B_HUMAN (1-126): 2.37e-52: 163: 96.03
+	Hs
		631445 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		H2B2E_HUMAN (1-126): 7.04e-55: 169: 98.41
+	Hs
		1066994 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		H2B2F_HUMAN (1-126): 2.99e-55: 170: 96.03
+	Hs
		631358 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		H2B1B_HUMAN (1-126): 1.3e-54: 168: 100.00
+	Hs
		631389 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		H2B1C_HUMAN (1-126): 1.27e-54: 168: 97.62
+	Hs
		707639 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		H2B1B_HUMAN (1-126): 1.3e-54: 168: 100.00
+	Hs
		918378 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		H2B1C_HUMAN (1-126): 1.27e-54: 168: 97.62
+	Hs
		319121 BRD1_HUMAN (197-781): 8.89e-33: 140: 13.99		H2B1O_HUMAN (1-126): 3.73e-55: 169: 97.62
+	Sc
		355953 RSC1_YEAST (87-841): 2.12e-39: 161: 12.50		H2B2_YEAST (3-125): 1.47e-40: 133: 70.73
+	Sc
		355988 GCN5_YEAST (140-462): 1.42e-41: 161: 16.37		H2B2_YEAST (3-125): 1.47e-40: 133: 70.73
+	Sc
		356020 RSC2_YEAST (87-766): 1.06e-38: 159: 13.49		H2B2_YEAST (3-125): 1.47e-40: 133: 70.73
+	Sp
		392629 YK82_SCHPO (49-215): 1.43e-35: 147: 26.35		H2B1_SCHPO (4-125): 1.37e-45: 145: 69.67
+	Sc
		355564 RSC1_YEAST (87-841): 2.12e-39: 161: 12.50		H2B1_YEAST (3-125): 4.34e-36: 121: 70.73
+	Sc
		355611 GCN5_YEAST (140-462): 1.42e-41: 161: 16.37		H2B1_YEAST (3-125): 4.34e-36: 121: 70.73
+	Sc
		355655 RSC2_YEAST (87-766): 1.06e-38: 159: 13.49		H2B1_YEAST (3-125): 4.34e-36: 121: 70.73