HitPredict

Interactor 1: LMX1B (O60663)
LIM homeobox transcription factor 1-beta (LIM/homeobox protein 1.2) (LMX-1.2) (LIM/homeobox protein LMX1B)
Gene: LMX1B

Interactor 2: SSBP4 (Q9BWG4)
Single-stranded DNA-binding protein 4
Gene: SSBP4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.691

Property	Details
Experiments	26186194, 28514442, 33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 402 Hs			1 385
+	Hs
		253026 LMX1B_HUMAN (1-402): 3.22e-102: 310: 100.00		SSBP3_HUMAN (6-385): 7.35e-54: 184: 70.03
+	Mm
		312698 LMX1B_MOUSE (1-402): 4.21e-97: 297: 98.01		Q3U4B1_MOUSE (1-385): 1.9e-54: 185: 83.68
+	Mm
		312711 LMX1B_MOUSE (1-402): 4.21e-97: 297: 98.01		SSBP3_MOUSE (6-385): 7.35e-54: 184: 70.03
+	Hs
		253011 LMX1B_HUMAN (1-402): 3.22e-102: 310: 100.00		SSBP2_HUMAN (1-385): 1.3e-43: 156: 69.51
+	Mm
		312710 LMX1B_MOUSE (1-402): 4.21e-97: 297: 98.01		SSBP2_MOUSE (1-385): 5.08e-44: 157: 69.77
+	Hs
		877555 LHX1_HUMAN (55-400): 6.64e-63: 209: 25.34		SSBP4_HUMAN (1-385): 6.03e-71: 228: 100.00
+	Hs
		961490 ISL1_HUMAN (49-389): 5.15e-58: 194: 27.75		SSBP4_HUMAN (1-385): 6.03e-71: 228: 100.00
+	Hs
		895791 LHX2_HUMAN (33-353): 3.25e-55: 189: 21.83		SSBP4_HUMAN (1-385): 6.03e-71: 228: 100.00
+	Hs
		1416155 LHX9_HUMAN (53-339): 6.91e-54: 185: 25.85		SSBP4_HUMAN (1-385): 6.03e-71: 228: 100.00
+	Hs
		877557 LHX1_HUMAN (55-400): 6.64e-63: 209: 25.34		SSBP3_HUMAN (6-385): 7.35e-54: 184: 70.03
+	Mm
		1423948 LHX2_MOUSE (33-353): 1.06e-57: 195: 22.10		SSBP3_MOUSE (6-385): 7.35e-54: 184: 70.03
+	Hs
		961491 ISL1_HUMAN (49-389): 5.15e-58: 194: 27.75		SSBP3_HUMAN (6-385): 7.35e-54: 184: 70.03
+	Mm
		961502 ISL1_MOUSE (49-389): 5.15e-58: 194: 27.75		SSBP3_MOUSE (6-385): 7.35e-54: 184: 70.03
+	Hs
		895792 LHX2_HUMAN (33-353): 3.25e-55: 189: 21.83		SSBP3_HUMAN (6-385): 7.35e-54: 184: 70.03
+	Hs
		1416425 LHX9_HUMAN (53-339): 6.91e-54: 185: 25.85		SSBP3_HUMAN (6-385): 7.35e-54: 184: 70.03
+	Hs
		877507 LHX1_HUMAN (55-400): 6.64e-63: 209: 25.34		SSBP2_HUMAN (1-385): 1.3e-43: 156: 69.51
+	Mm
		1423892 LHX2_MOUSE (33-353): 1.06e-57: 195: 22.10		SSBP2_MOUSE (1-385): 5.08e-44: 157: 69.77
+	Mm
		961501 ISL1_MOUSE (49-389): 5.15e-58: 194: 27.75		SSBP2_MOUSE (1-385): 5.08e-44: 157: 69.77
+	Hs
		961475 ISL1_HUMAN (49-389): 5.15e-58: 194: 27.75		SSBP2_HUMAN (1-385): 1.3e-43: 156: 69.51
+	Hs
		895698 LHX2_HUMAN (33-353): 3.25e-55: 189: 21.83		SSBP2_HUMAN (1-385): 1.3e-43: 156: 69.51