HitPredict

Interactor 1: CAPON (O75052)
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein)
Gene: NOS1AP

Interactor 2: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm GO:0098974 - postsynaptic actin cytoskeleton organization GO:0098978 - glutamatergic synapse
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 506 Hs			1 192
+	Hs
		253603 CAPON_HUMAN (1-506): 0: 552: 100.00		RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32
+	Hs
		253533 CAPON_HUMAN (1-506): 0: 552: 100.00		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49
+	Hs
		833571 NUMB_HUMAN (3-391): 5.91e-74: 247: 15.69		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		545266 NUMB_HUMAN (3-391): 5.91e-74: 247: 15.69		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Hs
		833656 NUMB_HUMAN (3-391): 5.91e-74: 247: 15.69		RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32
+	Hs
		833559 NUMB_HUMAN (3-391): 5.91e-74: 247: 15.69		RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00
+	Hs
		833576 NUMB_HUMAN (3-391): 5.91e-74: 247: 15.69		RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79
+	Hs
		833560 NUMB_HUMAN (3-391): 5.91e-74: 247: 15.69		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		833562 NUMB_HUMAN (3-391): 5.91e-74: 247: 15.69		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		436206 NUMB_HUMAN (3-391): 5.91e-74: 247: 15.69		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79
+	Hs
		564452 NUMB_HUMAN (3-391): 5.91e-74: 247: 15.69		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49
+	Hs
		925491 ANS1A_HUMAN (3-253): 1.16e-49: 185: 19.84		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		1331020 NUMBL_HUMAN (4-334): 2.15e-54: 194: 18.02		RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32
+	Hs
		892522 ANS1A_HUMAN (3-253): 1.16e-49: 185: 19.84		RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00
+	Hs
		564765 NUMBL_HUMAN (4-334): 2.15e-54: 194: 18.02		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49
+	Mm
		892714 ANS1B_MOUSE (3-224): 4.35e-48: 180: 22.27		RAC3_MOUSE (1-192): 5.54e-79: 235: 100.00
+	Hs
		900638 ANS1B_HUMAN (3-223): 4.12e-50: 186: 23.11		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		925248 JIP2_HUMAN (32-175): 4.48e-19: 92.8: 19.18		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71