Protein: RNF5
E3 ubiquitin-protein ligase RNF5 (EC 2.3.2.27) (RING finger protein 5) (Ram1 homolog) (HsRma1)

Gene: RNF5
Organism: Homo sapiens
Interactions: 152
UniProt ID: Q99942

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1381191

UB2E3
Ubiquitin-conjugating enzyme E2 E3

7

20

Small-scale

0.965

High

982298

UB2D2
Ubiquitin-conjugating enzyme E2 D2

7

20

Small-scale

0.962

High

957179

UB2D3
Ubiquitin-conjugating enzyme E2 D3

6

20

Small-scale

0.952

High

1408189

RNF5
E3 ubiquitin-protein ligase RNF5

6

17

Small-scale

0.947

High

957657

UBE2K
Ubiquitin-conjugating enzyme E2 K

5

20

High-throughput

0.931

High

906761

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

20

High-throughput

0.911

High

1397287

UB2E2
Ubiquitin-conjugating enzyme E2 E2

4

20

High-throughput

0.911

High

1408213

UB2D4
Ubiquitin-conjugating enzyme E2 D4

4

20

High-throughput

0.911

High

1383927

UBE2W
Ubiquitin-conjugating enzyme E2 W

2

20

High-throughput

0.834

High

1408215

UB2J1
Ubiquitin-conjugating enzyme E2 J1

2

20

Small-scale

0.789

High

909383

UB2E1
Ubiquitin-conjugating enzyme E2 E1

2

20

Small-scale

0.785

High

1391914

RN185
E3 ubiquitin-protein ligase RNF185

4

19

Small-scale

0.701

High

1408200

UBTD1
Ubiquitin domain-containing protein 1

2

3

High-throughput

0.700

High

1103933

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

20

High-throughput

0.698

High

1408199

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

20

High-throughput

0.698

High

1278088

MAVS
Mitochondrial antiviral-signaling protein

4

12

Small-scale

0.694

High

564281

CFTR
Cystic fibrosis transmembrane conductance regulator

4

6

Small-scale

0.687

High

1408193

DERL1
Derlin-1

4

10

Small-scale

0.686

High

845113

EAA3
Excitatory amino acid transporter 3

3

3

High-throughput

0.675

High

1408218

INSI2
Insulin-induced gene 2 protein

3

4

High-throughput

0.675

High

1352355

RHBL4
Rhomboid-related protein 4

3

3

High-throughput

0.665

High

1292868

STING
Stimulator of interferon genes protein

3

6

Small-scale

0.650

High

508516

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.647

High

952463

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

20

Small-scale

0.647

High

957826

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.647

High

1218750

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.625

High

856886

BAG6
Large proline-rich protein BAG6

1

20

Small-scale

0.618

High

1259224

TMUB2
Transmembrane and ubiquitin-like domain-containing protein 2

1

5

High-throughput

0.618

High

1408194

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

5

Small-scale

0.618

High

1333405

CYAC3
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3

3

2

High-throughput

0.616

High

1408195

YIPF2
Protein YIPF2

3

2

High-throughput

0.616

High

904089

BAP31
B-cell receptor-associated protein 31

2

4

Small-scale

0.611

High

144476

SCD
Stearoyl-CoA desaturase

2

1

High-throughput

0.606

High

549460

CD20
B-lymphocyte antigen CD20

2

1

High-throughput

0.606

High

1050054

PLP2
Proteolipid protein 2

2

1

High-throughput

0.606

High

1139250

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

2

1

High-throughput

0.606

High

1253306

DG2L6
Diacylglycerol O-acyltransferase 2-like protein 6

2

1

High-throughput

0.606

High

1313642

PLPP6
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

2

2

High-throughput

0.606

High

1322832

ORML3
ORM1-like protein 3

2

1

High-throughput

0.606

High

1408192

YIPF4
Protein YIPF4

2

3

High-throughput

0.606

High

1408210

PRAF1
Prenylated Rab acceptor protein 1

2

3

High-throughput

0.606

High

1408216

YIPF1
Protein YIPF1

2

2

High-throughput

0.606

High

878548

PAXI
Paxillin

1

16

Small-scale

0.596

High

1390567

Q96FI0
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.594

High

424254

S10A8
Protein S100-A8

2

13

Small-scale

0.584

High

944317

TMM33
Transmembrane protein 33

2

2

Small-scale

0.584

High

1408211

AMFR
E3 ubiquitin-protein ligase AMFR

2

14

Small-scale

0.584

High

1408202

S38A7
Sodium-coupled neutral amino acid transporter 7

2

2

High-throughput

0.583

High

1408204

CLN6
Ceroid-lipofuscinosis neuronal protein 6

2

1

Small-scale

0.571

High

710449

EPHA2
Ephrin type-A receptor 2

1

5

Small-scale

0.561

High

710655

EPHA3
Ephrin type-A receptor 3

1

6

Small-scale

0.561

High

932122

EPHA4
Ephrin type-A receptor 4

1

7

Small-scale

0.561

High

1239654

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

1

Small-scale

0.561

High

1287421

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

12

Small-scale

0.561

High

1361354

BRI3B
BRI3-binding protein

2

2

High-throughput

0.558

High

1408206

JKAMP
JNK1/MAPK8-associated membrane protein

1

0

Small-scale

0.554

High

257666

PRAF2
PRA1 family protein 2

2

2

High-throughput

0.553

High

1386925

F241B
Protein FAM241B

2

1

High-throughput

0.553

High

1394440

SC22A
Vesicle-trafficking protein SEC22a

1

0

High-throughput

0.549

High

178573

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

2

High-throughput

0.536

High

833859

P2RY2
P2Y purinoceptor 2

1

9

High-throughput

0.536

High

1057576

ACHD
Acetylcholine receptor subunit delta

1

2

High-throughput

0.536

High

1153312

AAAT
Neutral amino acid transporter B(0)

1

3

Small-scale

0.536

High

1197273

MBRL
Membralin

1

2

High-throughput

0.536

High

1231459

ATLA3
Atlastin-3

1

2

High-throughput

0.536

High

1382167

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

1400718

S38A2
Sodium-coupled neutral amino acid symporter 2

1

2

Small-scale

0.536

High

1403497

KCNKG
Potassium channel subfamily K member 16

1

1

High-throughput

0.536

High

1408201

GPR35
G-protein coupled receptor 35

1

10

High-throughput

0.536

High

1408217

SRPRB
Signal recognition particle receptor subunit beta

1

5

High-throughput

0.536

High

75527

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

883439

CY561
Transmembrane ascorbate-dependent reductase CYB561

1

2

High-throughput

0.523

High

1218644

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.515

High

1249653

ZDH24
Probable palmitoyltransferase ZDHHC24

1

1

High-throughput

0.515

High

1280807

S35E3
Solute carrier family 35 member E3

1

1

High-throughput

0.515

High

1386550

OPTN
Optineurin

1

20

High-throughput

0.515

High

1408207

ORML1
ORM1-like protein 1

1

1

High-throughput

0.515

High

253888

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.513

High

905660

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

1333485

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.513

High

1393481

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

2

Small-scale

0.512

High

220008

XRCC3
DNA repair protein XRCC3

1

3

High-throughput

0.489

High

354384

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

2

High-throughput

0.489

High

1279539

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

1

High-throughput

0.489

High

1329699

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

1

1

High-throughput

0.489

High

1351780

ST7L
Suppressor of tumorigenicity 7 protein-like

1

2

High-throughput

0.489

High

1405833

DNJC7
DnaJ homolog subfamily C member 7

1

7

High-throughput

0.489

High

1408190

TBA1C
Tubulin alpha-1C chain

1

15

High-throughput

0.489

High

639297

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

5

High-throughput

0.481

High

846091

GLP1R
Glucagon-like peptide 1 receptor

1

2

Small-scale

0.481

High

283343

ERLN1
Erlin-1

1

11

High-throughput

0.479

High

321341

ERLN2
Erlin-2

1

20

Small-scale

0.479

High

345106

RIGI
Antiviral innate immune response receptor RIG-I

1

15

Small-scale

0.479

High

367608

CAH2
Carbonic anhydrase 2

1

1

High-throughput

0.479

High

445055

S10A9
Protein S100-A9

1

14

High-throughput

0.479

High

458474

ADRB2
Beta-2 adrenergic receptor

1

4

High-throughput

0.479

High

459327

CATL1
Procathepsin L

1

2

High-throughput

0.479

High

773968

SOAT1
Sterol O-acyltransferase 1

1

2

High-throughput

0.479

High

934273

BI1
Bax inhibitor 1

1

3

High-throughput

0.479

High

1043231

TAP2
Antigen peptide transporter 2

1

4

Small-scale

0.479

High

1049713

1433F
14-3-3 protein eta

1

15

High-throughput

0.479

High

1085373

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

8

Small-scale

0.479

High

1249154

LMBRL
Protein LMBR1L

1

3

High-throughput

0.479

High

1294245

GOLI
E3 ubiquitin-protein ligase RNF130

1

12

High-throughput

0.479

High

1334529

RN149
E3 ubiquitin-protein ligase RNF149

1

11

High-throughput

0.479

High

1356230

RN139
E3 ubiquitin-protein ligase RNF139

1

10

High-throughput

0.479

High

1365496

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.479

High

1408191

SELS
Selenoprotein S

1

1

Small-scale

0.479

High

1408197

DERL2
Derlin-2

1

10

Small-scale

0.479

High

1408205

DJB12
DnaJ homolog subfamily B member 12

1

6

Small-scale

0.479

High

1408209

S12A6
Solute carrier family 12 member 6

1

4

Small-scale

0.479

High

1408219

PD2R2
Prostaglandin D2 receptor 2

1

10

High-throughput

0.479

High

460867

CATB
Cathepsin B

1

3

High-throughput

0.470

High

1408220

FHOD1
FH1/FH2 domain-containing protein 1

1

2

Small-scale

0.464

High

1105868

TMED1
Transmembrane emp24 domain-containing protein 1

1

0

High-throughput

0.458

High

1131810

LBR
Delta(14)-sterol reductase LBR

1

0

Small-scale

0.458

High

517295

ZTRF1
Zinc finger TRAF-type-containing protein 1

1

6

High-throughput

0.445

High

679389

DNJB2
DnaJ homolog subfamily B member 2

1

5

High-throughput

0.445

High

1068888

NIPA4
Magnesium transporter NIPA4

1

3

High-throughput

0.445

High

1196213

S22A6
Solute carrier family 22 member 6

1

8

High-throughput

0.445

High

1230840

SL9A4
Sodium/hydrogen exchanger 4

1

4

High-throughput

0.445

High

1247846

S4A10
Sodium-driven chloride bicarbonate exchanger

1

3

High-throughput

0.445

High

1335692

MOT11
Monocarboxylate transporter 11

1

6

High-throughput

0.445

High

1401540

S26A8
Testis anion transporter 1

1

4

High-throughput

0.445

High

1408196

S12A9
Solute carrier family 12 member 9

1

5

High-throughput

0.445

High

1408214

SC6A5
Sodium- and chloride-dependent glycine transporter 2

1

3

High-throughput

0.445

High

209654

SERA
D-3-phosphoglycerate dehydrogenase

1

5

Small-scale

0.437

High

294235

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.437

High

680740

CATS
Cathepsin S

1

2

High-throughput

0.437

High

831314

CCNF
Cyclin-F

1

5

High-throughput

0.437

High

877375

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

4

High-throughput

0.437

High

1066462

RBBP4
Histone-binding protein RBBP4

1

7

Small-scale

0.437

High

1161375

HIF1A
Hypoxia-inducible factor 1-alpha

1

8

Small-scale

0.437

High

1334831

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.437

High

1408198

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

380578

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

0

High-throughput

0.426

High

1251488

S36A4
Neutral amino acid uniporter 4

1

0

High-throughput

0.426

High

1408208

S23A1
Solute carrier family 23 member 1

1

0

High-throughput

0.426

High

1247732

S22AP
Solute carrier family 22 member 25

1

8

High-throughput

0.407

High

1408212

S45A1
Proton-associated sugar transporter A

1

2

High-throughput

0.407

High

350408

ABHGA
Phosphatidylserine lipase ABHD16A

4

0

Small-scale

0.367

High

49690

T120B
Transmembrane protein 120B

2

0

High-throughput

0.316

High

329658

LERL1
Leptin receptor overlapping transcript-like 1

2

0

High-throughput

0.316

High

1392156

RUSF1
RUS family member 1

2

0

High-throughput

0.316

High

1408203

TM242
Transmembrane protein 242

1

0

High-throughput

0.299

High

326158

REC8
Meiotic recombination protein REC8 homolog

1

0

Small-scale

0.249

Low

333709

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

0

High-throughput

0.249

Low

416764

TYSY
Thymidylate synthase

1

0

High-throughput

0.249

Low

557812

PEPD
Xaa-Pro dipeptidase

1

0

High-throughput

0.249

Low

976771

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

High-throughput

0.249

Low

1337036

TM104
Transmembrane protein 104

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025