Protein: GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6)

Gene: GAPD1, GAPVD1
Organism: Homo sapiens
Interactions: 111
UniProt ID: Q14C86

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005768 - endosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

830362

KC1E
Casein kinase I isoform epsilon

6

20

High-throughput

0.738

High

822018

KC1A
Casein kinase I isoform alpha

6

10

High-throughput

0.736

High

683356

1433B
14-3-3 protein beta/alpha

6

20

High-throughput

0.734

High

822264

KC1D
Casein kinase I isoform delta

5

9

High-throughput

0.720

High

904573

1433G
14-3-3 protein gamma

4

20

High-throughput

0.699

High

982022

1433F
14-3-3 protein eta

3

20

High-throughput

0.667

High

227479

PRKN
E3 ubiquitin-protein ligase parkin

3

12

High-throughput

0.640

High

601513

FGFR2
Fibroblast growth factor receptor 2

2

20

High-throughput

0.628

High

1061919

RAB35
Ras-related protein Rab-35

1

16

High-throughput

0.618

High

927058

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.611

High

1061935

KC1AL
Casein kinase I isoform alpha-like

2

14

High-throughput

0.611

High

1061933

MICU2
Calcium uptake protein 2, mitochondrial

3

12

High-throughput

0.609

High

1061953

TSSK1
Testis-specific serine/threonine-protein kinase 1

3

9

High-throughput

0.609

High

160570

AURKA
Aurora kinase A

2

9

High-throughput

0.584

High

1061969

SNX24
Sorting nexin-24

2

1

High-throughput

0.574

High

388450

HSPB1
Heat shock protein beta-1

1

4

High-throughput

0.541

High

165981

PER2
Period circadian protein homolog 2

1

4

High-throughput

0.536

High

170656

AXIN1
Axin-1

1

3

High-throughput

0.536

High

323763

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.536

High

617553

CRCM
Colorectal mutant cancer protein

1

8

High-throughput

0.536

High

871571

HSP72
Heat shock-related 70 kDa protein 2

1

11

High-throughput

0.536

High

909576

1433E
14-3-3 protein epsilon

1

11

High-throughput

0.536

High

1061937

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

5

High-throughput

0.536

High

1061947

EFMT3
EEF1A lysine methyltransferase 3

1

6

High-throughput

0.536

High

1061966

DS13B
Dual specificity protein phosphatase 13B

2

3

High-throughput

0.533

High

1061932

FBX11
F-box only protein 11

1

0

High-throughput

0.513

High

1061943

THRSP
Thyroid hormone-inducible hepatic protein

1

0

High-throughput

0.513

High

855796

VAV2
Guanine nucleotide exchange factor VAV2

1

13

High-throughput

0.508

High

1021056

FOXF1
Forkhead box protein F1

1

6

High-throughput

0.489

High

1021288

FOXL1
Forkhead box protein L1

1

6

High-throughput

0.489

High

1061938

F110D
Protein FAM110D

1

2

High-throughput

0.489

High

1061951

NPAS1
Neuronal PAS domain-containing protein 1

1

5

High-throughput

0.489

High

1061952

FOXB1
Forkhead box protein B1

1

6

High-throughput

0.489

High

162752

XPO1
Exportin-1

1

4

High-throughput

0.479

High

205405

TGON2
Trans-Golgi network integral membrane protein 2

1

7

High-throughput

0.479

High

229674

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

9

High-throughput

0.479

High

322646

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.479

High

384858

NTRK1
High affinity nerve growth factor receptor

1

17

High-throughput

0.479

High

455458

PARP1
Poly [ADP-ribose] polymerase 1

1

8

High-throughput

0.479

High

521937

CADH1
Cadherin-1

1

10

High-throughput

0.479

High

610406

CBL
E3 ubiquitin-protein ligase CBL

1

7

Small-scale

0.479

High

684044

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

684731

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.479

High

749507

BRCA1
Breast cancer type 1 susceptibility protein

1

7

High-throughput

0.479

High

779429

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

808618

YAP1
Transcriptional coactivator YAP1

1

10

High-throughput

0.479

High

835375

GSK3A
Glycogen synthase kinase-3 alpha

1

15

High-throughput

0.479

High

835764

GSK3B
Glycogen synthase kinase-3 beta

1

17

High-throughput

0.479

High

861758

PLK1
Serine/threonine-protein kinase PLK1

1

6

High-throughput

0.479

High

908556

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

932163

ACTC
Actin, alpha cardiac muscle 1

1

12

High-throughput

0.479

High

998722

EP300
Histone acetyltransferase p300

1

6

High-throughput

0.479

High

1030909

KCAB2
Voltage-gated potassium channel subunit beta-2

1

1

High-throughput

0.479

High

1035750

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

1036584

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

1038388

HDAC1
Histone deacetylase 1

1

2

High-throughput

0.479

High

1041599

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1061917

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.479

High

1061918

EEA1
Early endosome antigen 1

1

9

High-throughput

0.479

High

1061923

RN123
E3 ubiquitin-protein ligase RNF123

1

6

High-throughput

0.479

High

1061925

RNF43
E3 ubiquitin-protein ligase RNF43

1

5

High-throughput

0.479

High

1061926

LMBRL
Protein LMBR1L

1

2

High-throughput

0.479

High

1061936

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1061941

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

6

High-throughput

0.479

High

1061944

GOGA1
Golgin subfamily A member 1

1

5

High-throughput

0.479

High

1061950

RUFY1
RUN and FYVE domain-containing protein 1

1

13

High-throughput

0.479

High

1061955

WWTR1
WW domain-containing transcription regulator protein 1

1

9

High-throughput

0.479

High

1061956

CCDC8
Coiled-coil domain-containing protein 8

1

4

High-throughput

0.479

High

1061957

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1061958

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1061961

DUS22
Dual specificity protein phosphatase 22

1

2

High-throughput

0.479

High

1061963

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.479

High

1061964

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

6

High-throughput

0.479

High

1061965

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1061971

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

5

High-throughput

0.479

High

1061972

NS1BP
Influenza virus NS1A-binding protein

1

3

High-throughput

0.479

High

224438

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

961121

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1061929

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1061946

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

1061968

AGO2
Protein argonaute-2

1

0

Small-scale

0.458

High

902590

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.457

High

1061920

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.445

High

1061939

CE192
Centrosomal protein of 192 kDa

1

1

High-throughput

0.445

High

1061954

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

1061959

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.445

High

56531

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

4

High-throughput

0.437

High

100772

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

232172

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.437

High

536365

GLU2B
Glucosidase 2 subunit beta

1

2

High-throughput

0.437

High

708444

MCM4
DNA replication licensing factor MCM4

1

3

High-throughput

0.437

High

832469

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.437

High

940912

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.437

High

1055557

MCM6
DNA replication licensing factor MCM6

1

4

High-throughput

0.437

High

1061922

ZN618
Zinc finger protein 618

1

1

Small-scale

0.437

High

1061927

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.437

High

1061928

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.437

High

1061930

MGDP1
Magnesium-dependent phosphatase 1

1

1

High-throughput

0.437

High

1061931

HOOK3
Protein Hook homolog 3

1

12

High-throughput

0.437

High

1061934

SIR6
NAD-dependent protein deacylase sirtuin-6

1

5

High-throughput

0.437

High

1061940

DUS19
Dual specificity protein phosphatase 19

1

3

High-throughput

0.437

High

1061942

ESR2
Estrogen receptor beta

1

11

High-throughput

0.437

High

1061948

PF21A
PHD finger protein 21A

1

6

High-throughput

0.437

High

1061949

ARL5B
ADP-ribosylation factor-like protein 5B

1

13

High-throughput

0.437

High

1061960

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

5

High-throughput

0.437

High

1061921

SPT46
Spermatogenesis-associated protein 46

3

0

High-throughput

0.347

High

1061945

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.279

Low

1061962

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.279

Low

1061924

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

1061967

TF3C4
General transcription factor 3C polypeptide 4

1

0

High-throughput

0.249

Low

1061970

UFC1
Ubiquitin-fold modifier-conjugating enzyme 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024