HitPredict

Interactor 1: LRP5 (O75197)
Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7)
Gene: LRP5

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0006897 - endocytosis
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1615 Hs			1 191
+	Hs
		258347 LRP5_HUMAN (27-1615): 0: 1840: 100.00		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		258305 LRP5_HUMAN (27-1615): 0: 1840: 100.00		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		258304 LRP5_HUMAN (27-1615): 0: 1840: 100.00		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		258292 LRP5_HUMAN (27-1615): 0: 1840: 100.00		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		258302 LRP5_HUMAN (27-1615): 0: 1840: 100.00		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		270329 LRP6_HUMAN (8-646): 0: 590: 37.98		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		270285 LRP6_HUMAN (8-646): 0: 590: 37.98		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		564477 LRP2_HUMAN (1165-1411): 1.07e-11: 72.4: 11.33		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		254256 LRP4_HUMAN (1358-1590): 1.14e-11: 72.4: 10.04		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		925190 LRP2_HUMAN (1165-1411): 1.07e-11: 72.4: 11.33		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		893898 LRP2_HUMAN (1165-1411): 1.07e-11: 72.4: 11.33		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		900376 LRP2_HUMAN (1165-1411): 1.07e-11: 72.4: 11.33		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48