Protein: TRI59
Tripartite motif-containing protein 59 (EC 2.3.2.27) (RING finger protein 104) (Tumor suppressor TSBF-1)

Gene: TRI59, TRIM59
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q8IWR1

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0008270 - zinc ion binding
GO:0016567 - protein ubiquitination
GO:0043124 - negative regulation of canonical NF-kappaB signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1310690

UB2J2
Ubiquitin-conjugating enzyme E2 J2

2

20

High-throughput

0.783

High

1310693

ZDH22
Palmitoyltransferase ZDHHC22

5

1

High-throughput

0.722

High

827838

STAT3
Signal transducer and activator of transcription 3

4

5

Small-scale

0.676

High

1310701

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

4

0

High-throughput

0.668

High

508248

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

15

Small-scale

0.618

High

1310696

Q96FI0
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.594

High

1309049

ZDH21
Palmitoyltransferase ZDHHC21

2

0

High-throughput

0.580

High

1310697

SC22A
Vesicle-trafficking protein SEC22a

2

0

High-throughput

0.580

High

1310689

AGRG5
Adhesion G-protein coupled receptor G5

2

1

High-throughput

0.574

High

1310692

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

2

1

High-throughput

0.574

High

1121450

KEAP1
Kelch-like ECH-associated protein 1

1

5

Small-scale

0.561

High

1287370

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

4

Small-scale

0.561

High

1310695

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.555

High

1187728

KR133
Keratin-associated protein 13-3

2

2

High-throughput

0.553

High

1210068

SNP47
Synaptosomal-associated protein 47

2

1

High-throughput

0.553

High

1277095

PANKY
Photoreceptor ankyrin repeat protein

2

2

High-throughput

0.553

High

1310699

GO45
Golgin-45

2

1

High-throughput

0.553

High

931682

RD23B
UV excision repair protein RAD23 homolog B

1

16

Small-scale

0.553

High

1310698

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

Small-scale

0.529

High

1025483

CDK5
Cyclin-dependent kinase 5

1

12

Small-scale

0.528

High

277735

H2AY
Core histone macro-H2A.1

1

4

Small-scale

0.512

High

1109315

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.512

High

938168

PKNX1
Homeobox protein PKNOX1

1

2

High-throughput

0.494

High

290953

PPM1B
Protein phosphatase 1B

1

1

Small-scale

0.479

High

414163

P53
Cellular tumor antigen p53

1

8

Small-scale

0.479

High

466346

RHOC
Rho-related GTP-binding protein RhoC

1

6

High-throughput

0.479

High

1028271

MDM2
E3 ubiquitin-protein ligase Mdm2

1

5

Small-scale

0.479

High

906429

DHB4
Peroxisomal multifunctional enzyme type 2

1

6

High-throughput

0.470

High

1270893

RHOU
Rho-related GTP-binding protein RhoU

1

10

High-throughput

0.457

High

1310700

S39A1
Zinc transporter ZIP1

1

1

High-throughput

0.445

High

1310691

CCD33
Coiled-coil domain-containing protein 33

1

1

High-throughput

0.439

High

456785

ANXA2
Annexin A2

1

8

Small-scale

0.437

High

476165

ANXA5
Annexin A5

1

8

Small-scale

0.437

High

691221

1433T
14-3-3 protein theta

1

14

Small-scale

0.437

High

788318

GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4

1

2

Small-scale

0.437

High

911297

IMA5
Importin subunit alpha-5

1

7

Small-scale

0.437

High

951741

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.437

High

990467

1433Z
14-3-3 protein zeta/delta

1

14

Small-scale

0.437

High

1158133

MK14
Mitogen-activated protein kinase 14

1

9

High-throughput

0.437

High

1310688

NRM
Nurim

4

0

High-throughput

0.364

High

1310694

ABHD5
1-acylglycerol-3-phosphate O-acyltransferase ABHD5

3

0

Small-scale

0.347

High

71514

MEI4
Meiosis-specific protein MEI4

2

0

High-throughput

0.316

High

154498

CLD4
Claudin-4

2

0

High-throughput

0.316

High

914662

RM12
Large ribosomal subunit protein bL12m

2

0

High-throughput

0.316

High

1124204

EI2BA
Translation initiation factor eIF2B subunit alpha

2

0

High-throughput

0.316

High

1279942

NECA2
N-terminal EF-hand calcium-binding protein 2

2

0

High-throughput

0.316

High

1292461

RASF3
Ras association domain-containing protein 3

2

0

High-throughput

0.316

High

1310702

PLLP
Plasmolipin

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025