HitPredict

Interactor 1: BRD4 (O60885)
Bromodomain-containing protein 4 (Protein HUNK1)
Gene: BRD4

Interactor 2: UHRF2 (Q96PU4)
E3 ubiquitin-protein ligase UHRF2 (EC 2.3.2.27) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear protein 97) (Nuclear zinc finger protein Np97) (RING finger protein 107) (RING-type E3 ubiquitin transferase UHRF2) (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubiquitin-like-containing PHD and RING finger domains protein 2)
Gene: UHRF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	32416067
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Bromodomain~PHD
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0042393 - histone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1362 Hs			1 802
+	Hs
		260346 BRD4_HUMAN (1-1362): 1.08e-122: 416: 100.00		UHRF1_HUMAN (1-802): 0: 796: 52.76
+	Hs
		1141270 BRD3_HUMAN (37-737): 8.76e-57: 213: 47.73		UHRF2_HUMAN (1-802): 0: 947: 100.00
+	Hs
		1287976 PB1_HUMAN (15-951): 7.52e-20: 98.6: 11.32		UHRF2_HUMAN (1-802): 0: 947: 100.00
+	Hs
		1141277 BRD3_HUMAN (37-737): 8.76e-57: 213: 47.73		UHRF1_HUMAN (1-802): 0: 796: 52.76
+	Hs
		674300 BRD2_HUMAN (3-737): 5.3e-54: 206: 46.43		UHRF1_HUMAN (1-802): 0: 796: 52.76
+	Hs
		1369198 KAT2B_HUMAN (327-456): 5.64e-22: 105: 26.92		UHRF1_HUMAN (1-802): 0: 796: 52.76
+	Hs
		259867 BRD4_HUMAN (1-1362): 1.08e-122: 416: 100.00		CHD3_HUMAN (234-651): 1.76e-62: 231: 11.88
+	Hs
		259958 BRD4_HUMAN (1-1362): 1.08e-122: 416: 100.00		CHD4_HUMAN (291-651): 7.16e-59: 220: 13.13
+	Hs
		260577 BRD4_HUMAN (1-1362): 1.08e-122: 416: 100.00		KDM5B_HUMAN (251-428): 1.42e-41: 166: 18.09
+	Hs
		259570 BRD4_HUMAN (1-1362): 1.08e-122: 416: 100.00		KDM5C_HUMAN (251-428): 3.59e-35: 146: 16.36
+	Hs
		674151 BRD2_HUMAN (3-737): 5.3e-54: 206: 46.43		CHD3_HUMAN (234-651): 1.76e-62: 231: 11.88
+	Hs
		1132703 BRD3_HUMAN (37-737): 8.76e-57: 213: 47.73		CHD4_HUMAN (291-651): 7.16e-59: 220: 13.13
+	Hs
		674163 BRD2_HUMAN (3-737): 5.3e-54: 206: 46.43		CHD4_HUMAN (291-651): 7.16e-59: 220: 13.13
+	Hs
		342167 BRD1_HUMAN (192-769): 1.38e-30: 133: 13.50		CHD3_HUMAN (234-651): 1.76e-62: 231: 11.88
+	Hs
		342266 BRD1_HUMAN (192-769): 1.38e-30: 133: 13.50		CHD5_HUMAN (291-651): 4.3e-59: 221: 12.02
+	Hs
		342186 BRD1_HUMAN (192-769): 1.38e-30: 133: 13.50		CHD4_HUMAN (291-651): 7.16e-59: 220: 13.13
+	Hs
		1088423 PB1_HUMAN (15-951): 7.52e-20: 98.6: 11.32		CHD3_HUMAN (234-651): 1.76e-62: 231: 11.88
+	Hs
		1132793 PB1_HUMAN (15-951): 7.52e-20: 98.6: 11.32		CHD4_HUMAN (291-651): 7.16e-59: 220: 13.13
+	Hs
		1132858 PHIP_HUMAN (26-379): 6.93e-16: 85.9: 15.00		CHD4_HUMAN (291-651): 7.16e-59: 220: 13.13
+	Hs
		833749 PB1_HUMAN (15-951): 7.52e-20: 98.6: 11.32		KDM5C_HUMAN (251-428): 3.59e-35: 146: 16.36