HitPredict

Interactor 1: NCOR1 (O75376)
Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)
Gene: NCOR1

Interactor 2: ATX1 (P54253)
Ataxin-1 (Spinocerebellar ataxia type 1 protein)
Gene: ATXN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	16713569
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 2440 Hs			1 815
+	Hs
		868830 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		ATX1_HUMAN (1-815): 0: 1349: 100.00
+	Mm
		869311 NCOR2_MOUSE (1-2439): 3.58e-138: 486: 34.08		ATX1_MOUSE (1-815): 0: 1271: 86.89
+	Hs
		868703 MINT_HUMAN (468-2394): 3.2e-23: 111: 8.72		ATX1_HUMAN (1-815): 0: 1349: 100.00
+	Mm
		869002 MINT_MOUSE (40-2438): 7.95e-41: 169: 8.64		ATX1_MOUSE (1-815): 0: 1271: 86.89
+	Hs
		868698 CIC_HUMAN (505-2041): 4.4e-15: 84.3: 8.05		ATX1_HUMAN (1-815): 0: 1349: 100.00
+	Mm
		868991 MYH10_MOUSE (328-938): 7.73e-28: 126: 10.50		ATX1_MOUSE (1-815): 0: 1271: 86.89
+	Mm
		869164 CIC_MOUSE (571-2042): 8.47e-16: 86.6: 8.64		ATX1_MOUSE (1-815): 0: 1271: 86.89
+	Hs
		261378 NCOR1_HUMAN (1-2440): 0: 780: 100.00		ATX1L_HUMAN (1-815): 3.55e-108: 348: 27.15
+	Hs
		473582 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		ATX1L_HUMAN (1-815): 3.55e-108: 348: 27.15
+	Hs
		473553 CIC_HUMAN (505-2041): 4.4e-15: 84.3: 8.05		ATX1L_HUMAN (1-815): 3.55e-108: 348: 27.15