Protein: TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2)

Gene: TAB2
Organism: Homo sapiens
Interactions: 199
UniProt ID: Q9NYJ8

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005765 - lysosomal membrane
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508733

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

16

10

Small-scale

0.986

High

214050

M3K7
Mitogen-activated protein kinase kinase kinase 7

45

6

Small-scale

0.771

High

1452643

TRAF6
TNF receptor-associated factor 6

19

20

Small-scale

0.765

High

1153126

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

17

1

Small-scale

0.764

High

905695

IRAK1
Interleukin-1 receptor-associated kinase 1

8

1

Small-scale

0.747

High

378194

TNFA
Tumor necrosis factor

6

3

Small-scale

0.719

High

1452645

EMIL1
EMILIN-1

4

12

High-throughput

0.698

High

1090952

TRAF2
TNF receptor-associated factor 2

4

15

Small-scale

0.687

High

1109673

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

4

14

Small-scale

0.687

High

397086

ESR1
Estrogen receptor

3

20

Small-scale

0.678

High

584048

FOSL1
Fos-related antigen 1

3

10

High-throughput

0.667

High

966947

1433G
14-3-3 protein gamma

3

20

High-throughput

0.667

High

1049839

1433F
14-3-3 protein eta

3

20

High-throughput

0.667

High

1257262

RFPLB
Ret finger protein-like 4B

3

9

High-throughput

0.667

High

1452640

CARD8
Caspase recruitment domain-containing protein 8

3

1

High-throughput

0.667

High

1452637

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

3

1

High-throughput

0.665

High

1327558

TAB3
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

3

15

Small-scale

0.662

High

1452647

NEMO
NF-kappa-B essential modulator

3

8

Small-scale

0.661

High

1452627

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

3

13

Small-scale

0.661

High

1326557

CARME
Carnosine N-methyltransferase

4

0

High-throughput

0.661

High

1126775

BECN1
Beclin-1

2

2

Small-scale

0.649

High

1452649

NUMBL
Numb-like protein

2

4

Small-scale

0.642

High

278437

NCOR1
Nuclear receptor corepressor 1

2

20

Small-scale

0.639

High

1436634

TRI45
E3 ubiquitin-protein ligase TRIM45

2

20

Small-scale

0.634

High

1085146

SCRN1
Secernin-1

3

0

High-throughput

0.634

High

425652

ISG15
Ubiquitin-like protein ISG15

1

12

Small-scale

0.618

High

507394

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

10

High-throughput

0.618

High

475028

VIME
Vimentin

2

6

High-throughput

0.614

High

990799

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.614

High

347375

BAG2
BAG family molecular chaperone regulator 2

2

1

High-throughput

0.611

High

461986

HS90A
Heat shock protein HSP 90-alpha

2

8

Small-scale

0.611

High

1366599

AKAP1
A-kinase anchor protein 1, mitochondrial

2

1

High-throughput

0.611

High

447877

TPM3
Tropomyosin alpha-3 chain

2

1

High-throughput

0.606

High

1007548

KRT85
Keratin, type II cuticular Hb5

2

1

High-throughput

0.606

High

1323362

VPS52
Vacuolar protein sorting-associated protein 52 homolog

2

1

High-throughput

0.606

High

423325

A4
Amyloid-beta precursor protein

2

1

High-throughput

0.602

High

1332625

I17RC
Interleukin-17 receptor C

2

0

High-throughput

0.602

High

1081658

HSP7E
Heat shock 70 kDa protein 14

2

5

High-throughput

0.601

High

1400160

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

7

High-throughput

0.601

High

1452630

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

2

6

Small-scale

0.601

High

1351604

MIPT3
TRAF3-interacting protein 1

2

1

High-throughput

0.590

High

142701

TRI38
E3 ubiquitin-protein ligase TRIM38

2

11

Small-scale

0.584

High

520409

ANDR
Androgen receptor

2

20

Small-scale

0.584

High

697367

CD82
CD82 antigen

2

1

Small-scale

0.584

High

879543

NR2C2
Nuclear receptor subfamily 2 group C member 2

2

15

Small-scale

0.584

High

972065

1433E
14-3-3 protein epsilon

2

5

High-throughput

0.584

High

1005175

RNF4
E3 ubiquitin-protein ligase RNF4

2

2

Small-scale

0.584

High

1108218

SQSTM
Sequestosome-1

2

5

High-throughput

0.584

High

1227582

A16L1
Autophagy-related protein 16-1

2

8

High-throughput

0.584

High

1446975

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

2

4

Small-scale

0.584

High

269402

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

913908

ZN143
Zinc finger protein 143

2

0

High-throughput

0.580

High

626380

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

13

Small-scale

0.578

High

1389857

DC2I2
Cytoplasmic dynein 2 intermediate chain 2

1

14

Small-scale

0.573

High

188375

HDAC3
Histone deacetylase 3

1

13

Small-scale

0.561

High

1431894

PPIL3
Peptidyl-prolyl cis-trans isomerase-like 3

1

3

Small-scale

0.561

High

1452629

NLK
Serine/threonine-protein kinase NLK

1

3

Small-scale

0.561

High

1452633

TNIK
TRAF2 and NCK-interacting protein kinase

1

5

Small-scale

0.554

High

1145788

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

13

Small-scale

0.552

High

1051432

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

High-throughput

0.549

High

977599

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

2

High-throughput

0.541

High

1361926

TITIN
Titin

1

7

High-throughput

0.541

High

1228729

C102B
Coiled-coil domain-containing protein 102B

1

2

High-throughput

0.536

High

1428920

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

1

3

High-throughput

0.536

High

1429993

SHRPN
Sharpin

1

3

High-throughput

0.536

High

1452084

ANR10
Ankyrin repeat domain-containing protein 10

1

5

High-throughput

0.536

High

1241972

FBX42
F-box only protein 42

2

3

Small-scale

0.533

High

177724

SMAD7
Mothers against decapentaplegic homolog 7

1

4

Small-scale

0.529

High

1360025

EDAD
Ectodysplasin-A receptor-associated adapter protein

1

0

Small-scale

0.529

High

642593

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.518

High

1005979

GTF2I
General transcription factor II-I

1

0

High-throughput

0.518

High

1420288

S19A3
Thiamine transporter 2

1

0

High-throughput

0.518

High

214465

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

3

Small-scale

0.515

High

1022801

XIAP
E3 ubiquitin-protein ligase XIAP

1

4

Small-scale

0.515

High

1418817

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

4

Small-scale

0.515

High

1452648

TNR11
Tumor necrosis factor receptor superfamily member 11A

1

5

Small-scale

0.515

High

1063654

GOGA2
Golgin subfamily A member 2

1

8

High-throughput

0.515

High

549700

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.513

High

946680

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

0

High-throughput

0.513

High

1399066

TMM74
Transmembrane protein 74

1

0

High-throughput

0.513

High

1452644

PCDGE
Protocadherin gamma-B2

1

0

High-throughput

0.513

High

1452646

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

167983

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

6

Small-scale

0.501

High

261449

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

9

Small-scale

0.501

High

1110128

HDAC1
Histone deacetylase 1

1

15

Small-scale

0.501

High

1452636

HDAC5
Histone deacetylase 5

1

18

Small-scale

0.501

High

1449642

ZF64B
Zinc finger protein 64

1

0

High-throughput

0.493

High

999562

NOMO3
BOS complex subunit NOMO3

1

1

High-throughput

0.489

High

1278179

PK1L2
Polycystin-1-like protein 2

1

1

High-throughput

0.489

High

1353540

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

10

Small-scale

0.484

High

389543

FINC
Fibronectin

1

4

High-throughput

0.481

High

993779

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.480

High

143710

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

4

Small-scale

0.479

High

173468

XPO1
Exportin-1

1

12

High-throughput

0.479

High

177954

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

6

Small-scale

0.479

High

191242

TLR3
Toll-like receptor 3

1

3

Small-scale

0.479

High

271581

ATG13
Autophagy-related protein 13

1

2

Small-scale

0.479

High

294434

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

350155

SNAI1
Zinc finger protein SNAI1

1

3

High-throughput

0.479

High

352256

MBD3
Methyl-CpG-binding domain protein 3

1

3

Small-scale

0.479

High

404481

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

408179

TBB4A
Tubulin beta-4A chain

1

1

High-throughput

0.479

High

447518

NPM
Nucleophosmin

1

2

High-throughput

0.479

High

457745

TBB5
Tubulin beta chain

1

1

High-throughput

0.479

High

483233

CLCA
Clathrin light chain A

1

2

High-throughput

0.479

High

535603

BIP
Endoplasmic reticulum chaperone BiP

1

7

High-throughput

0.479

High

538018

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

572249

TRI27
Zinc finger protein RFP

1

12

Small-scale

0.479

High

584590

VAV
Proto-oncogene vav

1

5

High-throughput

0.479

High

589878

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

621774

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

622695

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

5

Small-scale

0.479

High

637763

FLNA
Filamin-A

1

2

High-throughput

0.479

High

643101

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

6

High-throughput

0.479

High

683352

TNR5
Tumor necrosis factor receptor superfamily member 5

1

6

Small-scale

0.479

High

691483

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

697678

PYR1
Multifunctional protein CAD

1

1

High-throughput

0.479

High

710905

EPHB2
Ephrin type-B receptor 2

1

5

Small-scale

0.479

High

727998

DNJA1
DnaJ homolog subfamily A member 1

1

2

High-throughput

0.479

High

729480

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

6

High-throughput

0.479

High

730921

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

801563

HSPA9
Stress-70 protein, mitochondrial

1

9

High-throughput

0.479

High

833377

PERI
Peripherin

1

6

High-throughput

0.479

High

834754

M3K8
Mitogen-activated protein kinase kinase kinase 8

1

1

Small-scale

0.479

High

840813

RS27
Small ribosomal subunit protein eS27

1

1

High-throughput

0.479

High

888353

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

930061

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

Small-scale

0.479

High

931138

HSP72
Heat shock-related 70 kDa protein 2

1

3

High-throughput

0.479

High

938298

SEC13
Protein SEC13 homolog

1

10

High-throughput

0.479

High

943662

SIK1
Serine/threonine-protein kinase SIK1

1

3

Small-scale

0.479

High

947292

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

4

Small-scale

0.479

High

957529

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

981987

RL23
Large ribosomal subunit protein uL14

1

1

High-throughput

0.479

High

993356

ACTG
Actin, cytoplasmic 2

1

16

High-throughput

0.479

High

1026252

CLH1
Clathrin heavy chain 1

1

1

High-throughput

0.479

High

1034361

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

11

High-throughput

0.479

High

1051876

EF1A2
Elongation factor 1-alpha 2

1

2

High-throughput

0.479

High

1096837

RFA4
Replication protein A 30 kDa subunit

1

6

High-throughput

0.479

High

1117512

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

6

High-throughput

0.479

High

1120977

TRI29
Tripartite motif-containing protein 29

1

16

Small-scale

0.479

High

1125244

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

13

Small-scale

0.479

High

1156232

ZYX
Zyxin

1

3

High-throughput

0.479

High

1158195

MK14
Mitogen-activated protein kinase 14

1

2

Small-scale

0.479

High

1160778

DREB
Drebrin

1

5

High-throughput

0.479

High

1192129

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

3

High-throughput

0.479

High

1229110

RNF43
E3 ubiquitin-protein ligase RNF43

1

4

High-throughput

0.479

High

1252259

SYNE3
Nesprin-3

1

8

High-throughput

0.479

High

1280558

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

10

High-throughput

0.479

High

1295584

MIB1
E3 ubiquitin-protein ligase MIB1

1

4

High-throughput

0.479

High

1315296

TRI22
E3 ubiquitin-protein ligase TRIM22

1

11

Small-scale

0.479

High

1322801

CNTRB
Centrobin

1

7

High-throughput

0.479

High

1350473

BICD2
Protein bicaudal D homolog 2

1

15

High-throughput

0.479

High

1364628

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

1367435

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1368649

KAT6A
Histone acetyltransferase KAT6A

1

20

High-throughput

0.479

High

1389404

RNF31
E3 ubiquitin-protein ligase RNF31

1

10

High-throughput

0.479

High

1391195

BICD1
Protein bicaudal D homolog 1

1

10

High-throughput

0.479

High

1396835

SNX27
Sorting nexin-27

1

13

High-throughput

0.479

High

1403031

SIN3A
Paired amphipathic helix protein Sin3a

1

4

Small-scale

0.479

High

1405567

TBX5
T-box transcription factor TBX5

1

10

High-throughput

0.479

High

1407919

ANM1
Protein arginine N-methyltransferase 1

1

7

High-throughput

0.479

High

1420001

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

9

Small-scale

0.479

High

1420574

TRIM5
Tripartite motif-containing protein 5

1

11

Small-scale

0.479

High

1435372

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1447717

PDLI7
PDZ and LIM domain protein 7

1

3

Small-scale

0.479

High

1452631

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1452632

XPO7
Exportin-7

1

11

High-throughput

0.479

High

1452634

UBP18
Ubl carboxyl-terminal hydrolase 18

1

6

Small-scale

0.479

High

1452638

RUVB2
RuvB-like 2

1

4

High-throughput

0.479

High

1452639

RUVB1
RuvB-like 1

1

4

High-throughput

0.479

High

1452641

SIK3
Serine/threonine-protein kinase SIK3

1

3

Small-scale

0.479

High

1452642

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

3

Small-scale

0.479

High

1452650

PIAS3
E3 SUMO-protein ligase PIAS3

1

2

Small-scale

0.479

High

551294

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

608946

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

0

High-throughput

0.458

High

669401

PAR1
Proteinase-activated receptor 1

1

0

Small-scale

0.458

High

787460

TGFR1
TGF-beta receptor type-1

1

0

Small-scale

0.458

High

1058325

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1083533

BST2
Bone marrow stromal antigen 2

1

0

Small-scale

0.458

High

1314556

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

1323172

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

High-throughput

0.458

High

1369502

TANK
TRAF family member-associated NF-kappa-B activator

1

0

Small-scale

0.458

High

1383695

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.458

High

1406904

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

1

0

Small-scale

0.458

High

530466

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.445

High

1103414

CTBP1
C-terminal-binding protein 1

1

3

High-throughput

0.445

High

1401888

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

1450276

EXOC1
Exocyst complex component 1

1

0

High-throughput

0.438

High

106747

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

1365518

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.437

High

1452635

Q9UQC1
Heat shock protein 72

1

6

High-throughput

0.437

High

1452628

MS18A
Protein Mis18-alpha

1

0

High-throughput

0.426

High

1436382

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.328

High

1433665

CST9L
Cystatin-9-like

1

0

High-throughput

0.282

High

279952

CISY
Citrate synthase, mitochondrial

1

0

High-throughput

0.269

Low

404614

TFF1
Trefoil factor 1

1

0

Small-scale

0.249

Low

1063884

LG3BP
Galectin-3-binding protein

1

0

High-throughput

0.249

Low

1385704

ENTR1
Endosome-associated-trafficking regulator 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025