HitPredict

Interactor 1: PR40A (O75400)
Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6)
Gene: PRPF40A

Interactor 2: RU2B (P08579)
U2 small nuclear ribonucleoprotein B'' (U2 snRNP B'')
Gene: SNRPB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005654 - nucleoplasm GO:0005685 - U1 snRNP GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 957 Hs			1 225
+	Hs
		263479 PR40A_HUMAN (1-957): 5.9e-97: 328: 100.00		SNRPA_HUMAN (2-225): 2.91e-42: 146: 48.56
+	Hs
		263528 PR40A_HUMAN (1-957): 5.9e-97: 328: 100.00		PTBP1_HUMAN (5-224): 4.18e-17: 81.2: 16.07
+	Hs
		235624 PR40A_HUMAN (1-957): 5.9e-97: 328: 100.00		HNRPQ_HUMAN (4-224): 8.43e-14: 71.6: 20.00
+	Hs
		61731 A6H8W8_HUMAN (41-720): 1.02e-38: 158: 10.02		RU2B_HUMAN (1-225): 5.14e-51: 166: 100.00
+	Hs
		441383 ITSN2_HUMAN (41-720): 9.42e-36: 149: 9.78		RU2B_HUMAN (1-225): 5.14e-51: 166: 100.00
+	Hs
		154731 TCRG1_HUMAN (6-820): 7.38e-41: 165: 16.47		SNRPA_HUMAN (2-225): 2.91e-42: 146: 48.56
+	Hs
		269199 WBP4_HUMAN (102-385): 6.66e-27: 115: 14.68		SNRPA_HUMAN (2-225): 2.91e-42: 146: 48.56
+	Hs
		643446 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		PTBP1_HUMAN (5-224): 4.18e-17: 81.2: 16.07
+	Hs
		125102 WWP2_HUMAN (4-227): 1.27e-13: 77.3: 12.86		RU2B_HUMAN (1-225): 5.14e-51: 166: 100.00
+	Sc
		703255 PRP40_YEAST (144-667): 4.38e-18: 91.1: 16.90		NAM8_YEAST (1-224): 5.12e-42: 150: 16.09
+	Hs
		235750 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		HNRPQ_HUMAN (4-224): 8.43e-14: 71.6: 20.00
+	Hs
		516402 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		PABP1_HUMAN (141-225): 2.1e-13: 70.5: 17.78
+	Hs
		808925 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		PABP3_HUMAN (141-225): 2.17e-12: 67.4: 17.78
+	Hs
		269205 WBP4_HUMAN (102-385): 6.66e-27: 115: 14.68		TIA1_HUMAN (2-160): 1.14e-16: 79.4: 13.04
+	Hs
		269201 WBP4_HUMAN (102-385): 6.66e-27: 115: 14.68		PABP1_HUMAN (141-225): 2.1e-13: 70.5: 17.78
+	Hs
		516643 ITCH_HUMAN (4-297): 3.34e-18: 92.1: 13.95		PABP1_HUMAN (141-225): 2.1e-13: 70.5: 17.78
+	Hs
		125167 WWP2_HUMAN (4-227): 1.27e-13: 77.3: 12.86		PTBP1_HUMAN (5-224): 4.18e-17: 81.2: 16.07
+	Hs
		320999 MYH10_HUMAN (432-957): 1.68e-14: 80.8: 9.98		PTBP3_HUMAN (4-224): 2.96e-13: 70.1: 15.35
+	Hs
		125031 WWP2_HUMAN (4-227): 1.27e-13: 77.3: 12.86		HNRPQ_HUMAN (4-224): 8.43e-14: 71.6: 20.00
+	Hs
		125122 WWP2_HUMAN (4-227): 1.27e-13: 77.3: 12.86		PABP1_HUMAN (141-225): 2.1e-13: 70.5: 17.78