HitPredict

Interactor 1: SRS10 (O75494)
Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)
Gene: SRSF10

Interactor 2: ZCH18 (Q86VM9)
Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1)
Gene: ZC3H18

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	28514442, 29298432, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0016607 - nuclear speck
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 262 Hs			1 953
+	Hs
		1201565 SRS12_HUMAN (1-251): 1.31e-38: 137: 46.33		ZCH18_HUMAN (1-953): 3.56e-83: 290: 100.00
+	Hs
		1201760 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		ZCH18_HUMAN (1-953): 3.56e-83: 290: 100.00
+	Hs
		952022 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		ZCH18_HUMAN (1-953): 3.56e-83: 290: 100.00
+	Hs
		964019 SRSF2_HUMAN (4-90): 1.89e-24: 99.3: 45.65		ZCH18_HUMAN (1-953): 3.56e-83: 290: 100.00
+	Hs
		516580 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		ZCH18_HUMAN (1-953): 3.56e-83: 290: 100.00
+	Hs
		267100 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		SRRM2_HUMAN (7-950): 3.04e-18: 92.9: 11.64
+	Hs
		1246388 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		THOC2_HUMAN (248-635): 6.8e-20: 98.2: 14.15
+	Hs
		1357564 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		SRRM2_HUMAN (7-950): 3.04e-18: 92.9: 11.64
+	Hs
		1222876 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		SRRM1_HUMAN (39-841): 2.51e-14: 79.8: 12.14
+	Hs
		952179 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		SRRM2_HUMAN (7-950): 3.04e-18: 92.9: 11.64
+	Hs
		516749 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		SRRM2_HUMAN (7-950): 3.04e-18: 92.9: 11.64
+	Hs
		952031 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		SRRM1_HUMAN (39-841): 2.51e-14: 79.8: 12.14
+	Hs
		964025 SRSF2_HUMAN (4-90): 1.89e-24: 99.3: 45.65		SRRM1_HUMAN (39-841): 2.51e-14: 79.8: 12.14
+	Hs
		1031405 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		TITIN_HUMAN (139-952): 5.65e-14: 79: 9.54
+	Hs
		516609 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		TITIN_HUMAN (139-952): 5.65e-14: 79: 9.54
+	Hs
		965152 PABP3_HUMAN (2-99): 1.17e-17: 84: 18.37		ANK2_HUMAN (498-952): 3.04e-11: 70.1: 14.63