HitPredict

Interactor 1: FOXH1 (O75593)
Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast-1) (hFAST-1) (Forkhead activin signal transducer 2) (Fast-2)
Gene: FOXH1

Interactor 2: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 0.60 0.757

The method score is based on:

Property Details
Experiments 15750622, 10938097, 10199400, 32296183, 9858566, 9389648, 9288972, 12732634, 21828274, 16916642, unassigned1304, 9702198
Identification Methods affinity chromatography technology, two hybrid, pull down, two hybrid prey pooling approach, two hybrid array, validated two hybrid, affinity technology
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003140 - determination of left/right asymmetry in lateral mesoderm
and 11 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 365
Hs

1 467
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Ce
+ Hs
+ Hs
+ Hs
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024