HitPredict

Interactor 1: PHAR2 (O75167)
Phosphatase and actin regulator 2
Gene: PHACTR2

Interactor 2: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.80	0.775

Property	Details
Experiments	30890647, 28514442, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~RPEL
Common GO terms	-
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 634 Hs			1 377
+	Hs
		273616 PHAR2_HUMAN (1-634): 3.42e-63: 222: 100.00		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		273621 PHAR2_HUMAN (1-634): 3.42e-63: 222: 100.00		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		273618 PHAR2_HUMAN (1-634): 3.42e-63: 222: 100.00		ACTA_HUMAN (1-377): 0: 597: 98.41
+	Hs
		995690 PHAR4_HUMAN (3-634): 1.01e-42: 165: 33.00		ACTC_HUMAN (1-377): 0: 599: 100.00
+	Hs
		952952 PHAR4_HUMAN (3-634): 1.01e-42: 165: 33.00		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		993242 PHAR4_HUMAN (3-634): 1.01e-42: 165: 33.00		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Dm
		534511 Q9VZM9_DROME (215-634): 5.44e-32: 134: 28.81		ACT1_DROME (1-377): 0: 598: 94.43
+	Hs
		995769 PHAR3_HUMAN (196-634): 1.86e-31: 131: 35.07		ACTC_HUMAN (1-377): 0: 599: 100.00
+	Hs
		953041 PHAR3_HUMAN (196-634): 1.86e-31: 131: 35.07		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Dm
		1014463 Q9VZM9_DROME (215-634): 5.44e-32: 134: 28.81		ACT6_DROME (1-377): 0: 594: 92.84
+	Hs
		3174 A0A0J9YVR0_HUMAN (2-188): 2.45e-33: 129: 37.37		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Dm
		534512 Q9VZN2_DROME (215-634): 2.15e-29: 126: 28.81		ACT1_DROME (1-377): 0: 598: 94.43
+	Hs
		953184 MACF1_HUMAN (456-631): 7.23e-26: 116: 16.84		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		590266 MUC1_HUMAN (5-488): 2.58e-23: 107: 10.76		ACTA_HUMAN (1-377): 0: 597: 98.41
+	Hs
		215916 SYNJ1_HUMAN (7-415): 3.83e-13: 75: 11.81		ACTC_HUMAN (1-377): 0: 599: 100.00
+	Hs
		996532 PHAR1_HUMAN (4-283): 1.73e-11: 69.2: 23.45		ACTS_HUMAN (1-377): 0: 599: 98.94