HitPredict

Interactor 1: PIAS2 (O75928)
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Gene: PIAS2

Interactor 2: TRI63 (Q969Q1)
E3 ubiquitin-protein ligase TRIM63 (EC 2.3.2.27) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (RING-type E3 ubiquitin transferase TRIM63) (Striated muscle RING zinc finger protein) (Tripartite motif-containing protein 63)
Gene: TRIM63

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	18157088
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0008270 - zinc ion binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 621 Hs			1 353
+	Hs
		278333 PIAS2_HUMAN (1-621): 0: 811: 100.00		TRI55_HUMAN (11-324): 8.5e-72: 234: 61.78
+	Hs
		278217 PIAS2_HUMAN (1-621): 0: 811: 100.00		TRI27_HUMAN (8-353): 1.89e-68: 225: 17.49
+	Hs
		1282085 PIAS3_HUMAN (1-621): 0: 666: 55.25		TRI63_HUMAN (1-326): 8.01e-81: 252: 100.00
+	Hs
		278144 PIAS1_HUMAN (1-621): 0: 653: 54.10		TRI63_HUMAN (1-326): 8.01e-81: 252: 100.00
+	Hs
		1317554 PIAS3_HUMAN (1-621): 0: 666: 55.25		TRI55_HUMAN (11-324): 8.5e-72: 234: 61.78
+	Hs
		537154 PIAS3_HUMAN (1-621): 0: 666: 55.25		TRI27_HUMAN (8-353): 1.89e-68: 225: 17.49
+	Hs
		278161 PIAS1_HUMAN (1-621): 0: 653: 54.10		TRI55_HUMAN (11-324): 8.5e-72: 234: 61.78
+	Hs
		278302 PIAS2_HUMAN (1-621): 0: 811: 100.00		TRI50_HUMAN (14-250): 3.59e-14: 75.1: 25.00
+	Hs
		1318360 PIAS3_HUMAN (1-621): 0: 666: 55.25		TRIM8_HUMAN (15-330): 6.11e-65: 216: 20.87
+	Hs
		278295 PIAS2_HUMAN (1-621): 0: 811: 100.00		TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49
+	Hs
		277914 PIAS1_HUMAN (1-621): 0: 653: 54.10		TRI27_HUMAN (8-353): 1.89e-68: 225: 17.49
+	Hs
		278162 PIAS1_HUMAN (1-621): 0: 653: 54.10		TRIM5_HUMAN (10-346): 1.16e-64: 214: 17.49
+	Hs
		536921 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		TRI27_HUMAN (8-353): 1.89e-68: 225: 17.49
+	Hs
		135032 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		TRI38_HUMAN (8-352): 1.89e-63: 210: 17.68
+	Hs
		1170889 ZMIZ2_HUMAN (75-611): 9.53e-81: 275: 21.80		TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49
+	Hs
		1172236 ZMIZ1_HUMAN (65-460): 1.71e-75: 262: 23.04		TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49