HitPredict

Interactor 1: PIAS2 (O75928)
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Gene: PIAS2

Interactor 2: EPAS1 (Q99814)
Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)
Gene: EPAS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20661221
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0016607 - nuclear speck GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 621 Hs			1 870
+	Hs
		278229 PIAS2_HUMAN (1-621): 0: 811: 100.00		ARNT_HUMAN (2-644): 5.31e-129: 407: 19.24
+	Hs
		278106 PIAS1_HUMAN (1-621): 0: 653: 54.10		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Hs
		1085606 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Hs
		1075404 PIAS3_HUMAN (1-621): 0: 666: 55.25		NCOA2_HUMAN (6-564): 4.76e-97: 334: 18.53
+	Hs
		278197 PIAS1_HUMAN (1-621): 0: 653: 54.10		NCOA3_HUMAN (6-565): 1.75e-97: 335: 17.47