HitPredict

Interactor 1: SC22B (O75396)
Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1)
Gene: SEC22B

Interactor 2: STX8 (Q9UNK0)
Syntaxin-8
Gene: STX8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin
Common GO terms	GO:0005484 - SNAP receptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 236
+	Hs
		249804 SC22B_HUMAN (1-215): 1.35e-90: 266: 100.00		STX10_HUMAN (3-221): 2.25e-51: 168: 17.39
+	Hs
		225883 SC22B_HUMAN (1-215): 1.35e-90: 266: 100.00		STX6_HUMAN (3-221): 2.27e-43: 148: 17.30
+	Dm
		305596 O77434_DROME (1-215): 1.02e-77: 233: 56.74		Q9VV76_DROME (4-223): 7.24e-43: 146: 24.32
+	Dm
		121831 M9PGI6_DROME (1-215): 5.4e-76: 229: 56.22		Q9VV76_DROME (4-223): 7.24e-43: 146: 24.32
+	Hs
		280081 SC22B_HUMAN (1-215): 1.35e-90: 266: 100.00		SNP29_HUMAN (10-207): 2.96e-28: 109: 20.50
+	Hs
		179768 SC22B_HUMAN (1-215): 1.35e-90: 266: 100.00		BET1_HUMAN (149-234): 6.34e-25: 96.8: 18.61
+	At
		866335 VA722_ARATH (31-199): 8.27e-74: 224: 23.39		SNP33_ARATH (11-210): 1.8e-38: 137: 15.69
+	At
		1456080 VA721_ARATH (31-199): 4.69e-73: 222: 22.81		SNP33_ARATH (11-210): 1.8e-38: 137: 15.69
+	Hs
		908065 VAMP7_HUMAN (31-198): 2.72e-62: 195: 22.62		STX8_HUMAN (1-218): 7.58e-47: 156: 100.00
+	Dm
		1263473 Q7JYX5_DROME (30-214): 6.09e-64: 199: 20.54		Q9VV76_DROME (4-223): 7.24e-43: 146: 24.32
+	Hs
		225968 VAMP7_HUMAN (31-198): 2.72e-62: 195: 22.62		STX6_HUMAN (3-221): 2.27e-43: 148: 17.30
+	Sc
		646264 SEC22_YEAST (1-215): 3.09e-66: 204: 35.65		TLG1_YEAST (2-220): 3.97e-32: 118: 15.07
+	Sc
		646225 SEC22_YEAST (1-215): 3.09e-66: 204: 35.65		VAM7_YEAST (46-211): 1.29e-25: 103: 21.56
+	Sc
		646213 SEC22_YEAST (1-215): 3.09e-66: 204: 35.65		BET1_YEAST (93-235): 4.91e-27: 102: 18.06
+	Hs
		343334 VAMP7_HUMAN (31-198): 2.72e-62: 195: 22.62		SNP29_HUMAN (10-207): 2.96e-28: 109: 20.50
+	Dm
		305598 O77434_DROME (1-215): 1.02e-77: 233: 56.74		Q9VVX6_DROME (161-234): 4.71e-13: 65.7: 20.00
+	Dm
		121833 M9PGI6_DROME (1-215): 5.4e-76: 229: 56.22		Q9VVX6_DROME (161-234): 4.71e-13: 65.7: 20.00
+	Hs
		179853 VAMP7_HUMAN (31-198): 2.72e-62: 195: 22.62		BET1_HUMAN (149-234): 6.34e-25: 96.8: 18.61
+	Rn
		1204259 YKT6_RAT (30-188): 8.92e-53: 170: 23.13		BET1_RAT (149-234): 6.71e-26: 99.1: 22.09
+	Dm
		1263475 Q7JYX5_DROME (30-214): 6.09e-64: 199: 20.54		Q9VVX6_DROME (161-234): 4.71e-13: 65.7: 20.00