HitPredict

Interactor 1: KRT34 (O76011)
Keratin, type I cuticular Ha4 (Hair keratin, type I Ha4) (Keratin-34) (K34)
Gene: KRT34

Interactor 2: K22E (P35908)
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)
Gene: KRT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	36949045
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005615 - extracellular space GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0008544 - epidermis development GO:0045109 - intermediate filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 394 Hs			1 639
+	Hs
		409116 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33
+	Hs
		380631 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94
+	Hs
		1149205 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C73_HUMAN (1-598): 8.9e-92: 296: 51.00
+	Hs
		318825 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C75_HUMAN (1-582): 6e-90: 291: 53.58
+	Hs
		1055208 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		KRT81_HUMAN (72-491): 2.86e-87: 282: 48.46
+	Hs
		943678 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		KRT85_HUMAN (5-491): 4.47e-87: 282: 45.59
+	Hs
		213959 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		KRT86_HUMAN (72-557): 8.74e-87: 281: 44.35
+	Hs
		943639 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		KRT83_HUMAN (83-491): 2.11e-86: 280: 49.02
+	Hs
		531587 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48
+	Hs
		380488 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C6B_HUMAN (5-510): 8.35e-82: 270: 61.22
+	Hs
		1110335 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C71_HUMAN (1-570): 6.15e-82: 269: 51.23
+	Hs
		821668 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C6C_HUMAN (5-510): 2.02e-81: 269: 61.61
+	Hs
		1140432 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C79_HUMAN (32-568): 4.69e-80: 264: 55.35
+	Hs
		359503 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C6A_HUMAN (5-510): 8.33e-78: 259: 61.22
+	Hs
		1062054 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C72_HUMAN (87-494): 7.09e-77: 255: 61.28
+	Hs
		1149190 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C74_HUMAN (1-563): 1.33e-76: 255: 51.69
+	Hs
		965435 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K22O_HUMAN (1-506): 1.14e-73: 250: 63.95
+	Hs
		580138 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C4_HUMAN (11-509): 2.24e-73: 246: 59.72
+	Hs
		729113 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K22E_HUMAN (1-517): 4.22e-68: 235: 100.00
+	Hs
		517761 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C3_HUMAN (27-494): 2.18e-66: 230: 64.32