HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: DDX21 (Q9NR30)
Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu)
Gene: DDX21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	24457600, 26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Helicase_C~WD40
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 Hs			1 783
+	Mm
		1362762 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		DDX21_MOUSE (2-783): 2.1e-164: 499: 78.13
+	Mm
		1283488 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		DDX42_MOUSE (2-775): 1.04e-138: 434: 20.72
+	Hs
		141231 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		DDX3X_HUMAN (5-575): 1.07e-138: 426: 23.55
+	Hs
		285349 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		DDX42_HUMAN (2-766): 1.85e-135: 426: 20.30
+	Hs
		285438 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		DDX50_HUMAN (49-728): 6.63e-138: 426: 59.12
+	Mm
		1362605 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		DDX50_MOUSE (80-728): 2.1e-137: 425: 60.66
+	Mm
		1223843 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		DDX3X_MOUSE (5-575): 1.04e-137: 424: 23.55
+	Hs
		285396 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		DDX17_HUMAN (122-628): 4.51e-137: 424: 24.46
+	Mm
		1197468 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		DDX17_MOUSE (122-628): 9.19e-136: 418: 24.46
+	Mm
		1297361 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		Q8BTS0_MOUSE (92-620): 4.64e-136: 417: 24.81
+	Hs
		285069 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		DDX5_HUMAN (92-620): 1.19e-135: 417: 24.81
+	Hs
		1380188 FBXW7_HUMAN (219-439): 2.95e-26: 113: 15.32		DDX21_HUMAN (1-783): 0: 548: 100.00
+	Hs
		193129 POC1A_HUMAN (230-440): 1.55e-37: 142: 14.54		DDX3Y_HUMAN (5-581): 3.19e-133: 412: 23.99
+	Hs
		141604 FBXW7_HUMAN (219-439): 2.95e-26: 113: 15.32		DDX3X_HUMAN (5-575): 1.07e-138: 426: 23.55
+	Hs
		1369337 FBXW7_HUMAN (219-439): 2.95e-26: 113: 15.32		DDX17_HUMAN (122-628): 4.51e-137: 424: 24.46
+	Hs
		1369406 NLE1_HUMAN (296-440): 9.08e-25: 108: 16.45		DDX17_HUMAN (122-628): 4.51e-137: 424: 24.46
+	Hs
		608695 SNR40_HUMAN (298-441): 2.31e-21: 96.6: 14.29		DDX5_HUMAN (92-620): 1.19e-135: 417: 24.81
+	Hs
		285121 EED_HUMAN (1-441): 1.63e-90: 283: 100.00		IF4A3_HUMAN (169-554): 5.08e-54: 194: 32.23
+	Mm
		1362196 EED_MOUSE (1-441): 1.63e-90: 283: 100.00		IF4A3_MOUSE (169-554): 8.46e-54: 193: 31.97
+	Sc
		444583 COPA_YEAST (9-295): 5.36e-29: 122: 11.15		DED1_YEAST (196-541): 2.99e-56: 205: 37.98