HitPredict

Interactor 1: KS6A5 (O75582)
Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL)
Gene: RPS6KA5

Interactor 2: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	37827155, 21988832
Identification Methods	proximity labelling technology, two hybrid, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 802 Hs			1 616
+	Hs
		695537 KS6A1_HUMAN (6-752): 0: 712: 39.97		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		696817 KS6A6_HUMAN (3-753): 0: 684: 39.50		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		694977 KS6A3_HUMAN (366-776): 1.85e-106: 344: 23.47		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		694721 AKT2_HUMAN (365-708): 1.2e-103: 329: 29.36		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		605562 KAPCA_HUMAN (422-737): 1.77e-99: 314: 27.66		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		694720 AKT1_HUMAN (375-708): 5.47e-98: 314: 26.14		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		658566 KS6B1_HUMAN (393-797): 1.45e-94: 307: 22.92		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Dm
		1174410 Q94533_DROME (395-798): 1.3e-88: 290: 21.23		RFA1_DROME (1-614): 0: 619: 41.00
+	Hs
		694820 KPCI_HUMAN (401-676): 1.6e-25: 114: 27.59		RFA1_HUMAN (1-616): 0: 781: 100.00