HitPredict

Interactor 1: GRAP2 (O89100)
GRB2-related adaptor protein 2 (Adapter protein GRID) (GADS protein) (GRB-2-like protein) (GRB2L) (GRB-2-related monocytic adapter protein) (MONA) (Monocytic adapter) (GRBLG) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adaptor protein GrpL)
Gene: GRAP2

Interactor 2: KIT (P05532)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
Gene: KIT

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	9872323
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 322 Mm			1 979
+	Hs
		275165 GRAP2_HUMAN (1-322): 7.19e-63: 204: 72.42		KIT_HUMAN (1-978): 0: 795: 79.55
+	Hs
		433539 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		KIT_HUMAN (1-978): 0: 795: 79.55
+	Hs
		337322 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		KIT_HUMAN (1-978): 0: 795: 79.55
+	Hs
		499249 BLK_HUMAN (3-146): 7.8e-53: 182: 28.66		KIT_HUMAN (1-978): 0: 795: 79.55
+	Hs
		499228 PLCG2_HUMAN (9-321): 5.88e-33: 130: 18.21		KIT_HUMAN (1-978): 0: 795: 79.55
+	Mm
		292680 GRAP2_MOUSE (1-322): 4.39e-68: 217: 100.00		CSF1R_MOUSE (34-935): 0: 649: 37.84
+	Rn
		595729 LYN_RAT (3-136): 1.38e-55: 190: 31.76		PGFRA_RAT (16-962): 0: 632: 33.17
+	Hs
		337317 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		PGFRB_HUMAN (30-974): 0: 607: 30.29
+	Mm
		452188 PLCG2_MOUSE (9-321): 1.66e-31: 126: 17.05		CSF1R_MOUSE (34-935): 0: 649: 37.84
+	Hs
		433624 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		FLT3_HUMAN (14-976): 3.65e-177: 543: 30.41
+	Hs
		337376 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		FLT3_HUMAN (14-976): 3.65e-177: 543: 30.41
+	Hs
		738179 BLK_HUMAN (3-146): 7.8e-53: 182: 28.66		FLT3_HUMAN (14-976): 3.65e-177: 543: 30.41
+	Hs
		562650 PLCG2_HUMAN (9-321): 5.88e-33: 130: 18.21		NTRK3_HUMAN (283-927): 7.67e-132: 420: 20.66
+	Hs
		433573 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		FGFR2_HUMAN (7-326): 3.5e-56: 211: 12.77
+	Hs
		433576 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		FGFR4_HUMAN (22-322): 8.7e-42: 167: 12.36
+	Hs
		507835 PLCG2_HUMAN (9-321): 5.88e-33: 130: 18.21		FGFR1_HUMAN (8-326): 2.76e-53: 202: 15.16
+	Hs
		433742 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		PTK7_HUMAN (130-553): 5.56e-31: 133: 14.65
+	Dm
		112243 CRK_DROME (48-320): 8.25e-48: 163: 20.94		M9MRE1_DROME (31-500): 5.07e-33: 140: 17.51
+	Hs
		275162 GRAP2_HUMAN (1-322): 7.19e-63: 204: 72.42		CSF1R_HUMAN (9-322): 2.32e-14: 79.8: 13.80
+	Hs
		426976 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		CSF1R_HUMAN (9-322): 2.32e-14: 79.8: 13.80