HitPredict

Interactor 1: STK10 (O94804)
Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase)
Gene: STK10

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 968 Hs			1 779
+	Hs
		647959 MARK3_HUMAN (10-757): 1.97e-167: 509: 16.34		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1183121 MARK2_HUMAN (19-757): 4.5e-163: 499: 16.08		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1331749 MRCKB_HUMAN (2-967): 2.23e-149: 485: 15.63		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1137906 MRCKA_HUMAN (4-899): 1.54e-141: 464: 16.08		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1331496 MARK1_HUMAN (10-757): 4.39e-149: 463: 15.71		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1035207 ROCK1_HUMAN (1-968): 1.2e-138: 450: 17.51		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		254513 ROCK2_HUMAN (1-965): 7.61e-137: 446: 16.85		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		682210 AKT2_HUMAN (10-363): 1.39e-127: 396: 22.65		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1329364 SLK_HUMAN (1-953): 9.72e-119: 394: 32.38		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1027433 STK3_HUMAN (17-364): 1.76e-115: 365: 39.54		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1023113 STK4_HUMAN (17-324): 2.83e-115: 364: 41.88		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		131607 STK25_HUMAN (21-397): 3.16e-115: 362: 36.94		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1035386 MARK2_HUMAN (19-757): 4.5e-163: 499: 16.08		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Mm
		1169650 TAOK2_MOUSE (9-946): 4.2e-149: 475: 19.98		CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40
+	Ce
		136788 SULU_CAEEL (19-960): 2.01e-136: 435: 20.91		UNC89_CAEEL (146-660): 3.62e-58: 218: 12.35
+	Hs
		1035167 ROCK1_HUMAN (1-968): 1.2e-138: 450: 17.51		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Mm
		659464 KCC2B_MOUSE (30-550): 6.23e-136: 420: 17.28		CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40
+	Ce
		136783 O17566_CAEEL (1-700): 1.25e-105: 358: 30.22		UNC89_CAEEL (146-660): 3.62e-58: 218: 12.35
+	Hs
		1027413 STK3_HUMAN (17-364): 1.76e-115: 365: 39.54		CNKR1_HUMAN (17-260): 6.93e-38: 153: 22.84
+	Hs
		1023089 STK4_HUMAN (17-324): 2.83e-115: 364: 41.88		CNKR1_HUMAN (17-260): 6.93e-38: 153: 22.84