HitPredict

Interactor 1: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Interactor 2: STAM1 (Q92783)
Signal transducing adapter molecule 1 (STAM-1)
Gene: STAM

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.80	0.594

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 806 Hs			1 540
+	Hs
		296445 EPHA3_HUMAN (1-786): 0: 641: 20.68		STAM2_HUMAN (1-533): 4.56e-123: 373: 54.46
+	Hs
		931879 EPHA5_HUMAN (1-777): 0: 621: 20.18		STAM1_HUMAN (1-518): 7.99e-128: 386: 100.00
+	Hs
		296503 EPHA7_HUMAN (1-782): 0: 623: 21.22		STAM2_HUMAN (1-533): 4.56e-123: 373: 54.46
+	Hs
		296471 EPHA5_HUMAN (1-777): 0: 621: 20.18		STAM2_HUMAN (1-533): 4.56e-123: 373: 54.46
+	Hs
		296472 EPHA4_HUMAN (1-781): 0: 619: 20.78		STAM2_HUMAN (1-533): 4.56e-123: 373: 54.46
+	Hs
		710667 EPHA3_HUMAN (1-786): 0: 641: 20.68		GGA3_HUMAN (1-530): 8.61e-66: 228: 15.64
+	Hs
		931906 EPHA5_HUMAN (1-777): 0: 621: 20.18		GGA3_HUMAN (1-530): 8.61e-66: 228: 15.64
+	Hs
		169448 EPHA3_HUMAN (1-786): 0: 641: 20.68		HGS_HUMAN (84-540): 1.19e-13: 75.9: 13.50
+	Hs
		932029 EPHB1_HUMAN (6-781): 0: 643: 18.30		GRB2_HUMAN (215-265): 2.33e-13: 71.2: 54.90
+	Hs
		710618 EPHA3_HUMAN (1-786): 0: 641: 20.68		GRB2_HUMAN (215-265): 2.33e-13: 71.2: 54.90
+	Hs
		169450 EPHB2_HUMAN (6-788): 0: 629: 19.23		HGS_HUMAN (84-540): 1.19e-13: 75.9: 13.50
+	Hs
		710805 EPHB2_HUMAN (6-788): 0: 629: 19.23		GRB2_HUMAN (215-265): 2.33e-13: 71.2: 54.90
+	Mm
		932044 EPHB2_MOUSE (6-788): 0: 628: 19.11		GRB2_MOUSE (215-265): 2.66e-13: 71.2: 54.90
+	Hs
		169558 EPHA7_HUMAN (1-782): 0: 623: 21.22		HGS_HUMAN (84-540): 1.19e-13: 75.9: 13.50
+	Hs
		169489 EPHA5_HUMAN (1-777): 0: 621: 20.18		HGS_HUMAN (84-540): 1.19e-13: 75.9: 13.50
+	Hs
		169490 EPHA4_HUMAN (1-781): 0: 619: 20.78		HGS_HUMAN (84-540): 1.19e-13: 75.9: 13.50
+	Hs
		987657 EPHA7_HUMAN (1-782): 0: 623: 21.22		GRB2_HUMAN (215-265): 2.33e-13: 71.2: 54.90
+	Hs
		931831 EPHA5_HUMAN (1-777): 0: 621: 20.18		GRB2_HUMAN (215-265): 2.33e-13: 71.2: 54.90
+	Hs
		932053 EPHA4_HUMAN (1-781): 0: 619: 20.78		GRB2_HUMAN (215-265): 2.33e-13: 71.2: 54.90
+	Hs
		169781 EPHA6_HUMAN (3-774): 0: 595: 20.17		HGS_HUMAN (84-540): 1.19e-13: 75.9: 13.50