HitPredict

Interactor 1: GFPT2 (O94808)
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 2) (Glutamine:fructose-6-phosphate amidotransferase 2) (GFAT 2) (GFAT2) (Hexosephosphate aminotransferase 2)
Gene: GFPT2

Interactor 2: SIR6 (Q8N6T7)
NAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-) (Regulatory protein SIR2 homolog 6) (hSIRT6) (SIR2-like protein 6)
Gene: SIRT6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.50	0.599

Property	Details
Experiments	26186194, 33961781, 34244565
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 682 Hs			1 355
+	Hs
		986531 GFPT1_HUMAN (1-682): 0: 981: 77.25		SIR6_HUMAN (1-355): 2.25e-166: 469: 100.00
+	Hs
		986550 GFPT1_HUMAN (1-682): 0: 981: 77.25		SIR7_HUMAN (22-321): 2.13e-101: 306: 38.61
+	Sc
		373477 PUR1_YEAST (1-307): 2.77e-73: 247: 16.88		HST2_YEAST (31-272): 3.57e-76: 240: 23.59