HitPredict

Interactor 1: PKHG5 (O94827)
Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Guanine nucleotide exchange factor 720) (GEF720)
Gene: PLEKHG5

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20811643
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007266 - Rho protein signal transduction GO:0030027 - lamellipodium GO:0043123 - positive regulation of canonical NF-kappaB signal transduction and 1 others more... GO:0043542 - endothelial cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1006 Hs			1 193
+	Mm
		1146468 PKHG5_MOUSE (1-1006): 0: 762: 82.99		RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48
+	Hs
		900530 PKHG6_HUMAN (175-1006): 5.42e-116: 377: 32.11		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925320 PKHG6_HUMAN (175-1006): 5.42e-116: 377: 32.11		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		900913 PKHG2_HUMAN (331-978): 1.26e-96: 335: 19.10		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925622 PKHG2_HUMAN (331-978): 1.26e-96: 335: 19.10		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		894439 PKHG2_HUMAN (331-978): 1.26e-96: 335: 19.10		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		900768 ARHG2_HUMAN (215-990): 4.66e-94: 322: 16.51		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925497 ARHG2_HUMAN (215-990): 4.66e-94: 322: 16.51		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		900985 ARHGC_HUMAN (126-955): 4.18e-90: 318: 17.21		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		894169 FGD2_HUMAN (251-904): 5.15e-98: 325: 16.35		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		894320 FGD4_HUMAN (155-916): 5.87e-97: 325: 13.72		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		167078 ARHGB_HUMAN (121-975): 2.43e-88: 312: 17.22		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		436545 ARHGC_HUMAN (126-955): 4.18e-90: 318: 17.21		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		894523 ARHGC_HUMAN (126-955): 4.18e-90: 318: 17.21		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		167063 ARHGB_HUMAN (121-975): 2.43e-88: 312: 17.22		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		915884 ARHG2_HUMAN (215-990): 4.66e-94: 322: 16.51		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		167077 ARHGB_HUMAN (121-975): 2.43e-88: 312: 17.22		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		892637 ARHGC_HUMAN (126-955): 4.18e-90: 318: 17.21		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		916029 ARHGC_HUMAN (126-955): 4.18e-90: 318: 17.21		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		167079 ARHGB_HUMAN (121-975): 2.43e-88: 312: 17.22		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94