HitPredict

Interactor 1: PKHG5 (O94827)
Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Guanine nucleotide exchange factor 720) (GEF720)
Gene: PLEKHG5

Interactor 2: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1006 Hs			1 255
+	Hs
		909883 ARHG2_HUMAN (215-990): 4.66e-94: 322: 16.51		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909717 FGD6_HUMAN (152-838): 1.41e-83: 298: 16.52		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909491 AKP13_HUMAN (198-862): 8.63e-82: 294: 15.87		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909551 ARHG7_HUMAN (146-891): 9.12e-85: 293: 13.52		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		910068 ARHG4_HUMAN (304-767): 4.99e-84: 288: 14.92		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909921 SPT13_HUMAN (89-771): 5.32e-84: 286: 13.40		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909803 ARG28_HUMAN (207-845): 7.79e-78: 281: 16.35		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Mm
		910228 ARG28_MOUSE (146-845): 4.05e-77: 279: 16.64		1433E_MOUSE (1-255): 4.87e-154: 430: 100.00
+	Hs
		909662 ARHGG_HUMAN (319-692): 1.53e-73: 259: 20.95		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909781 ARHGJ_HUMAN (330-545): 2.73e-09: 63.2: 26.27		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00