HitPredict

Interactor 1: NEMO (O88522)
NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: Ikbkg

Interactor 2: RHOA (Q9QUI0)
Transforming protein RhoA (EC 3.6.5.2)
Gene: RHOA

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24240172
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Mm			1 193
+	Hs
		962690 NEMO_HUMAN (1-412): 4.78e-70: 228: 86.40		RHOA_HUMAN (1-193): 5.82e-81: 240: 99.48
+	Hs
		581153 MY18B_HUMAN (35-384): 1.04e-45: 171: 14.54		RAC2_HUMAN (1-193): 1.51e-76: 229: 53.61
+	Hs
		962366 OPTN_HUMAN (67-411): 2.67e-37: 144: 26.40		RHOA_HUMAN (1-193): 5.82e-81: 240: 99.48
+	Hs
		988600 OPTN_HUMAN (67-411): 2.67e-37: 144: 26.40		RAC1_HUMAN (1-193): 6.82e-80: 237: 57.22
+	Hs
		955207 ITSN1_HUMAN (12-368): 9.75e-38: 147: 15.31		CDC42_HUMAN (1-193): 1.23e-76: 229: 52.33
+	Hs
		978032 ITSN1_HUMAN (12-368): 9.75e-38: 147: 15.31		RHOB_HUMAN (1-191): 7.04e-74: 222: 83.94
+	Hs
		988821 MYO5B_HUMAN (61-387): 2.18e-30: 125: 15.54		RAC1_HUMAN (1-193): 6.82e-80: 237: 57.22
+	Hs
		962335 MY18A_HUMAN (38-382): 4.77e-27: 116: 17.31		RHOA_HUMAN (1-193): 5.82e-81: 240: 99.48
+	Hs
		988695 TARA_HUMAN (19-279): 5.2e-28: 118: 19.05		RAC1_HUMAN (1-193): 6.82e-80: 237: 57.22
+	Hs
		988578 MY18A_HUMAN (38-382): 4.77e-27: 116: 17.31		RAC1_HUMAN (1-193): 6.82e-80: 237: 57.22
+	Hs
		1015771 TARA_HUMAN (19-279): 5.2e-28: 118: 19.05		RHOG_HUMAN (1-193): 4.06e-77: 230: 54.40
+	Hs
		581208 MY18A_HUMAN (38-382): 4.77e-27: 116: 17.31		RAC2_HUMAN (1-193): 1.51e-76: 229: 53.61
+	Hs
		955437 MY18A_HUMAN (38-382): 4.77e-27: 116: 17.31		CDC42_HUMAN (1-193): 1.23e-76: 229: 52.33
+	Hs
		581399 MRCKB_HUMAN (26-348): 1.01e-26: 115: 14.93		RAC2_HUMAN (1-193): 1.51e-76: 229: 53.61
+	Hs
		955794 MRCKB_HUMAN (26-348): 1.01e-26: 115: 14.93		CDC42_HUMAN (1-193): 1.23e-76: 229: 52.33
+	Hs
		953664 TARA_HUMAN (19-279): 5.2e-28: 118: 19.05		RAC3_HUMAN (1-179): 8.03e-74: 222: 57.54
+	Hs
		978293 TARA_HUMAN (19-279): 5.2e-28: 118: 19.05		RHOB_HUMAN (1-191): 7.04e-74: 222: 83.94
+	Hs
		953598 MY18A_HUMAN (38-382): 4.77e-27: 116: 17.31		RAC3_HUMAN (1-179): 8.03e-74: 222: 57.54
+	Hs
		978205 MY18A_HUMAN (38-382): 4.77e-27: 116: 17.31		RHOB_HUMAN (1-191): 7.04e-74: 222: 83.94
+	Hs
		953780 MRCKB_HUMAN (26-348): 1.01e-26: 115: 14.93		RAC3_HUMAN (1-179): 8.03e-74: 222: 57.54