HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.84 1.00 0.922

The method score is based on:

Property Details
Experiments 32707033, 21233212, 34079125, 33961781, 24255178
Identification Methods affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase, Pkinase~Pkinase_C, Pkinase~UBA
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000922 - spindle pole
GO:0001827 - inner cell mass cell fate commitment
GO:0001828 - inner cell mass cellular morphogenesis
GO:0004674 - protein serine/threonine kinase activity
and 15 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 1130
Hs

1 1088
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024