HitPredict

Interactor 1: PAK4 (O96013)
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)
Gene: PAK4

Interactor 2: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	30639242, 30194290, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 591 Hs			1 189
+	Hs
		330801 PAK4_HUMAN (1-591): 0: 586: 100.00		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		331013 PAK4_HUMAN (1-591): 0: 586: 100.00		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		330934 PAK4_HUMAN (1-591): 0: 586: 100.00		RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97
+	Hs
		349667 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		682177 AKT2_HUMAN (261-583): 1.6e-127: 384: 22.94		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		349916 AKT2_HUMAN (261-583): 1.6e-127: 384: 22.94		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		682159 AKT2_HUMAN (261-583): 1.6e-127: 384: 22.94		RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97
+	Hs
		349336 KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		348674 KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		349992 KS6A3_HUMAN (265-591): 5.2e-113: 355: 24.27		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		350188 KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		348766 M4K3_HUMAN (316-574): 1.61e-52: 195: 40.00		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		350320 M4K3_HUMAN (316-574): 1.61e-52: 195: 40.00		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		350133 PAK2_HUMAN (8-161): 8.45e-26: 113: 16.67		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		897884 PAK2_HUMAN (8-161): 8.45e-26: 113: 16.67		RAP1B_HUMAN (1-165): 1.02e-62: 193: 57.49
+	Hs
		1026199 PAK1_HUMAN (3-210): 7.55e-29: 122: 19.62		RIT1_HUMAN (3-176): 8.94e-56: 177: 50.29